Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Study on the In Vitro Sun Protection Factor Effect of Nanosuspensions Prepared Using Bead Mill and High Pressure Homogenizer

비드밀과 고압 호모게나이저를 이용한 나노 분산체의 제조 및 자외선 차단 효과에 대한 연구

  • Published : 2005.12.20
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Abstract

The aim of the present work was to prepare the nanosuspension of inorganic pigment which shows light reflection and scattering as efficient sunscreen. The zinc oxide (ZnO) was chosen as an inorganic pigment, and high pressure homogenizer and bead mill have been used for the preparation of nanosuspension. The ZnO nanosuspensions were characterized by particle size, in vitro sun protection factor (SPF) and UV transmittance. ZnO nanosuspension prepared by bead mill showed the average diameter of $119{\pm}4\;nm$, resulting in the high value of SPF $(28.74{\pm}2.06,\;n=20)$, while that prepared by high pressure homogenizer showed the average diameter of $751{\pm}32\;nm$ with the relative lower value of SPF $(21.38{\pm}1.94\;n=20)$. In addition, the film of ZnO nanosuspension prepared by bead mill was showed a high visible ray (VIS) transmittance, indicating a high transparency. In conclusion, a physically stable ZnO nanosuspension in cyclomethicone was successfully prepared using bead mill for the suitable sunscreen preparations.

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References

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