Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Isolation of Urease Inhibitory Compounds from Arecae Semen

빈랑자 (Arecae Semen)로부터 Urease 억제 활성 물질의 분리

  • 류제만 ((주) 동화약품 중앙연구소 천연물 연구실) ;
  • 장환봉 ((주) 동화약품 중앙연구소 천연물 연구실) ;
  • 노양국 ((주) 동화약품 중앙연구소 천연물 연구실) ;
  • 오성준 ((주) 동화약품 중앙연구소 천연물 연구실) ;
  • 이현용 ((주) 동화약품 중앙연구소 천연물 연구실) ;
  • 임문정 ((주) 동화약품 중앙연구소 천연물 연구실)
  • Published : 2005.03.30
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Abstract

Urease plays an important role in the urea metabolism and the effect of urease activity on human and environment is enormous. For instance, urease acts as a virulence factor of the urinary and gastrointestinal tracts infections in human and animal, being involved in kidney stone formation, catheter encrusatation, pyelonephritis, ammonia encephalopathy, hepatic coma, and urinary tract infections. Widespread urease activity in soil induces a plant damage due to ammonia toxicity and pH increase. Therefore, urease activity regulation through urease inhibitors would lead to an enhanced efficiency of urea nitrogen uptake in plants and to the improved therapeutic strategies for ureolytic bacterial infections. To search for new inhibitory compounds on urease activity from herbs, MeOH extracts of herbs were screened. Among of them, the MeOH extracts of Areca catechu exhibited an excellent inhibitory effect on urease activity. Two compounds were isolated from the ethyl acetate fraction by the activity guided fractionation. Their chemical structures were identified as (+)-catechin(compound I) and allantoin(compound II) by spectroscopic evidence, respectively. Compound I showed a stronger inhibitory effect on urease activity than compound II.

Keywords

References

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