Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Monoamine Oxidase Inhibitor from Uncaria rhynchophylla

  • Hong, Seong-Su (College of Pharmacy, Chungbuk National University) ;
  • Han, Xiang Hua (College of Pharmacy, Chungbuk National University) ;
  • Park, So-Young (College of Pharmacy, Chungbuk National University) ;
  • Choi, Woo-Hoi (College of Pharmacy, Chungbuk National University) ;
  • Lee, Myung-Koo (College of Pharmacy, Chungbuk National University,Research Center for Bioresource and Health, Chungbuk National University) ;
  • Hur, Jae-Doo (Crown Pharmaceutical Co. Ltd.) ;
  • Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University) ;
  • Ro, Jai-Seup (College of Pharmacy, Chungbuk National University)
  • Published : 2005.09.01
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Abstract

A methanol soluble extract from the dried hooks and stems of Uncaria rhynchophylla showed a strong inhibitory activity against monoamine oxidase in mouse brain. Using a bioassay-guided purification of this extract, a known ${\beta}-carboline$ type alkaloid, harman (1), was obtained as an active constituent. In addition, five known indole alkaloids, isocorynoxeine (2), isorhynchophylline (3), corynoxeine (4), cadambine (5), and $3{\alpha}-dihydrocadambine$ (6), were isolated and found to be weakly active or inactive.

Keywords

References

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