대한한의학방제학회지 (Herbal Formula Science)

  • 제13권1호
  • /
  • Pages.103-121
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  • 2005
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  • 1229-1218(pISSN)
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  • 2288-5641(eISSN)
대한한의학방제학회 (The Korean Medicine Society for the Herbal Formula Study)
권호 표지

CT99 발현 신경 세포주에서 익기안신탕(益氣安神湯)의 신경보호 및 항치매 효과

Effect of the neuroprotetion and anti-Alzheimer's disease in CT99-induced Neuro 2A cells by Ikgiansintang water extract

  • 황연규 (대구한의대학교 한의학과 내과학) ;
  • 이소연 (대구한의대학교 한의학과 내과학) ;
  • 윤현덕 (대구한의대학교 한의학과 내과학) ;
  • 신오철 (대구한의대학교 한의학과 내과학) ;
  • 박창국 (대구한의대학교 한의학과 내과학) ;
  • 박치상 (대구한의대학교 한의학과 내과학)
  • Hwang, Yeon-Kyu (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Lee, So-Yeon (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Yoon, Hyeon-Deok (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Shin, Oh-Chul (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Park, Chang-Gook (Department of Oriental Medicine Graduate school of Daegu Haany University) ;
  • Park, Chi-Sang (Department of Oriental Medicine Graduate school of Daegu Haany University)
  • 발행 : 2005.06.30
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초록

Alzheimer's disease(AD) is a geriatric dementia that is widespread in old age. In the near future AD will be the biggest problem in public health service. It has been widely believed that $A{\beta}$ peptide devided from APP causes apoptotic neurotoxicity in AD brain. However, recent evidence suggests that n99 may be an important factor causing neurotoxicity in AD. Mouse Neuro 2A cells expressed with CT99 exhibited remarkable apoptotic cell damage. We invesgated the protective effects of Ikgiansintang water extract(IGA). Findings from our experiment have shown that IGA inhibits the activities of CT99, which has neurotoxicities and apoptotic activities in cell line. In addition treatment of IGA($50{\mu}g/ml$ for 24 hours) partially prevented CT99-induced cytotoxicity in Neuro 2A cells. As the result of this study, In IGA group, the apoptosis in the nervous system is inhibited, the repair against the degerneration of Neuro 2A cells by n99 expression is promoted. Base on these findings, IGA may be beneficial for the treatment of AD.

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