대한본초학회지 (The Korea Journal of Herbology)
- 제20권3호
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- Pages.29-41
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- 2005
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- 1229-1765(pISSN)
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- 2288-7199(eISSN)
개오동나무에서 추출(抽出)한 Catalposide의 항염(抗炎) 및 세포고사(細胞枯死) 억제효과(抑制效果)에 관(關)한 연구(硏究)
Studies on the Anti-inflammatory and Anti-apoptotic Effect of Catalposide Isolated from Catalpa ovata
- 오천식 (원광대학교 한의과대학 본초학교실) ;
- 황상욱 (원광대학교 한의과대학 본초학교실) ;
- 김영우 (원광대학교 한의과대학 본초학교실) ;
- 송달수 (원광대학교 한의과대학 본초학교실) ;
- 채영석 (원광대학교 한의과대학 본초학교실) ;
- 정종길 (동신대학교 한의과대학 방제학교실) ;
- 송호준 (원광대학교 한의과대학 본초학교실) ;
- 신민교 (원광대학교 한의과대학 본초학교실)
- Oh, Cheon-Sik (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Hwang, Sang-Wook (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Kim, Yong-Woo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Song, Dal-Soo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Chae, Young-Seok (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Jeong, Jong-Gil (Dept. of Prescriptions, College of Oriental Medicine, Dongshin University) ;
- Song, Ho-Joon (Dept. of Herbology, College of Oriental Medicine, Wonkwang University) ;
- Shin, Min-Kyo (Dept. of Herbology, College of Oriental Medicine, Wonkwang University)
- 발행 : 2005.09.30
초록
Objectives : The use of natural products with therapeutic properties is as ancient as human civilisation and, for a long time, mineral, plant and animal products were the main sources of drugs. Catalposide, the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don (Bignoniceae) has been shown to possess anti-microbial and anti-tumoral properties. Heme oxygenase-1 (HO-1) is a stress response protein and is known to play a protective role against the oxidative injury. In this study, we examined whether catalposide could protect Neuro 2A cells, a kind of neuronal cell lines, from oxidative damage through the induction of HO-1 protein expression and HO activity. We also examined the effects of catalposide on the productions of tumor necrosis