대한본초학회지 (The Korea Journal of Herbology)

  • 제20권3호
  • /
  • Pages.59-65
  • /
  • 2005
  • /
  • 1229-1765(pISSN)
  • /
  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지

CCK로 유발시킨 급성 췌장염에 대한 가미대황목단피탕의 효과

Effects of Gami-Daehwangmokdanpi-Tang against CCK-induced acute pancreatitis

  • 박성주 (원광대학교 한의과대학 본초학교실) ;
  • 정종길 (동신대학교 한의과대학) ;
  • 서상완 (원광대학교 한의과대학 본초학교실) ;
  • 황상욱 (원광대학교 한의과대학 본초학교실) ;
  • 김영우 (원광대학교 한의과대학 본초학교실) ;
  • 송달수 (원광대학교 한의과대학 본초학교실) ;
  • 채영석 (원광대학교 한의과대학 본초학교실) ;
  • 신민교 (원광대학교 한의과대학 본초학교실) ;
  • 송호준 (원광대학교 한의과대학 본초학교실)
  • Park, Sung-Joo (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Jeong, Jong-Gil (College of Oriental Medicine Dongshin University) ;
  • Seo, Sang-Wan (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Hwang, Sang-Wook (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Kim, Yong-Woo (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Song, Dal-Soo (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Chae, Young-Seok (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Shin, Min-Kyo (Dept. of Herbology, college of Oriental Medicine, Wonkwang University) ;
  • Song, Ho-Joon (Dept. of Herbology, college of Oriental Medicine, Wonkwang University)
  • 발행 : 2005.09.30
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초록

Objective : Daehwangmokdanpi-Tang (DWT) has been frequently used as a remedy for antiinflamation. To evaluate effect of acute pancreatitis by DWT, we examined the effects of DWT on the cholecystokinin-octapeptide (CCK)-induced acute pancreatitis (AP) in rats. Methods : Male Wistar rats weighing 200 to 250 g were divided into three groups. Normal untreated group, in treatment with DWT group; DWT was administered orally, followed by $75\;{\mu}g/kg$ CCK subcutaneously three times, after 1, 3 and 5 h. This whole procedure was repeated for 5 days. In treatment with saline group, the protocol was the same as in treatment group with DWT. Results : The author determined the pancreatic weight/body weight ratio, the levels of pancreatic HSP (heat shock protein)60 and HSP72 and the secretion of pro-inflammatory cytokines. Repeated CCK treatment resulted in the typical laboratory and morphological changes of experimentally induced pancreatitis. DWT was significantly decreased the pancreatic weight/body weight ratio in CCK-induced AP. Futhermore, The author demonstrated that DWT increased HSP60 and HSP72 compared with CCK-induced AP. Additionally, the secretion of $IL-1{\beta}\;and\;TNF-{\alpha}$ and the levels of amylase and lipase were lower than that saline. Conclusions : These results suggested that DWT may has a protective effect against CCK-induced AP.

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