Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Aqueous Extract of Rosa rugosa Radix Dilates Vascular Smooth Muscle Via a NO-cGMP Pathway

  • Lee, Jun-Kyoung (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Li, Hua Cao (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI), Wonkwang University) ;
  • Lee, Hyuck (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Jang, Ji-Yeon (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI), Wonkwang University)
  • Published : 2005.06.25
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Abstract

While conducting an in vitro screening of various medicinal plant extracts, an aqueous extract of Rosa rugosa Radix (ARR) was found to exhibit a distinct vasorelaxant activity. ARR induced a concentration-dependent relaxation of the phenylephrine-precontracted aorta. This effect disappeared with the removal of functional endothelium. Pretreatment of the aortic tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-]-quinoxalin-1-one (ODQ) completely inhibited the relaxation induced by ARR. ARR-induced vascular relaxations were also markedly attenuated by addition of diltiazem or verapamil. However, the relaxant effect of ARR was not blocked by pretreatment with indomethacine, tetraethylammonium (TEA), glibenclamide, atropine, or propranolol. Taken together, the present study suggests that ARR dilates vascular smooth muscle via endothelium-dependent NO/cGMP signaling.

Keywords

References

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