Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Talc on Cyclophosphamide-Induced Cystitis in the Rat

Cyclophosphamide유발 방광염에 대한 활석의 효능

  • Ryu, Ji-Won (Department of Anatomy, College of Oriental Medicine, Dong-Eui University) ;
  • Hong, Eun-Suk (Yangcheon Elementary School) ;
  • Choi, Yung-Hyun (Department of Biochemistry, College of Oriental Medicine, Dong-Eui University) ;
  • Lee, Yong-Tae (Department of Physiology.Biomedical Research Center of Oriental Medicine, College of Oriental Medicine, dong-Eui University) ;
  • Choi, Byung-Tae (Department of Anatomy, College of Oriental Medicine, Dong-Eui University)
  • 유지원 (동의대학교 한의과대학 해부학교실) ;
  • 홍은숙 (양천초등학교) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 이용태 (동의대학교 한의과대학 생리학교실.한방바이오연구센터) ;
  • 최병태 (동의대학교 한의과대학 해부학교실)
  • Published : 2005.04.25
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Abstract

We investigated the effects of aqueous extract from talc for suppression in the process of cyclophosphamide-induced cystitis in the rat. The weight of urinary bladder was increased in the cyclophosphamide-injected rat compared with normal, but the increase of weight was arrested by intake of talc. More similar results showed in the uric test involving nitrate content and blood cell number and serum analysis involving the content of blood urea nitrogen and uric acid in the talc challenged rat compared with control one. More severe histological changes of urinary bladder such as edema, wall thickness, bleeding, vacuolation in mucosal epithelium were demonstrated in the rat injected with cyclophosphamide compared with normal. Fewer scores of these changes such as edema and bleeding were observed in rats treated with talc. In the immunohistochemical analysis, the expression of inflammatory-related protein examined tended to increase in the urinary bladder of cyclophosphamide-injected rat, especially COX-2 and $TNF-{\alpha}$ in mucosal epithelium and iNOS and $IL-1{\beta}$ in mucosal and muscular layer. The decline of these immunoreation were observed in the talc treated rat, significant decrease of COX-2 was detected in mucosal epithelium and iNOS in submucosal layer. These results suggest that talc may use as a useful therapeutic agent for noninfectious cystitis.

Keywords

References

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