Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Black Raspberry Wine on Estrogen in Sprague-Dawley Rats

복분자 술이 흰쥐의 estrogen에 미치는 영향

  • Lim, Chae-Woong (College of Veterinary Medicine, Chonbuk National University) ;
  • Choi, Yun-Gi (College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Sung-Il (Toyama Medical and Pharmaceutical University) ;
  • Jeon, Byung-Hun (College of Oriental Medicine, Wonkwang University) ;
  • Baek, Byeong-Kirl (College of Veterinary Medicine, Chonbuk National University)
  • Published : 2005.04.25
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Abstract

This study was conducted to investigate the effects of black raspberry wine which was administered per os on estrogen levels in Splague-Dawley(SD) rats. Black raspberry wine containing 13% alcohol(v/v) was prepared from ripe fruits of Rubus coreanus fermented with Saccharomyces cervisiae. The rats were divided into 2 groups(A and B): The group A received black raspberry wine and the group B received saline for 7 weeks. All animals were bi weekly monitored for estrogen levels by radioimmunoassay using $125^I$ labeled anti-estrogen monospecific antibody. There was a significant(2.02 fold) increase in estrogen levels in the group A with a peak at the 7th week post administration of black raspberry wine. There was no significant change in estrogen levels of the rats in the group B. These data point to uncharacterized phytoestrogenic bioactivity of black raspberry wine that appears to be a useful phytoestrogenic herbal remedy for human health.

Keywords

References

  1. Lee, S.H., Jung, B.H., Kim, S.Y., Chung, B.C Determination of phytoestrogens in traditional medicinal herbs using gas chromatography-mass spectrometry. J Nutr Biochem. 15(8):452-460, 2004.
  2. Kang, H.J., Ansbacher, R., Hammoud, M.M. Use of alternative and complementary medicine in menopause. International Journal of Gynecology & Obstetrics. 79:195-207, 2002.
  3. Wang, X., Wu, J., Chiba, H., Umegaki, K., Yamada, K., Ishimi, Y. Puerariae radix prevents bone loss in ovariectomized mice. J Bone Miner Metab. 21(5):268-275, 2003.
  4. Dailey, R.K., Neale, A.V., Northrup, J., West, P., Schwartz , K.L. Herbal product use and menopause symptom relief in primary care patients: a MetroNet study. symptoms. J Womens Health(Larchmt). 12(7): 633-641, 2003.
  5. Foster, R.H., Balfour, J.A. Estradiol and dydrogesterone. A review of their combined use as hormone replacement therapy in postmenopausal women. Drugs Aging. 11(4):309-332, 1997.
  6. Shenouda, N.S., Zhou, C., Browning, J.D., Ansell, P.J., Sakla, M.S., Lubahn, D.B., Macdonald, .R.S. Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer. 49(2):200-208, 2004.
  7. Kris-Etherton, P.M., Hecker, K.D., Bonanome, A., Coval, S.M., Binkoski, A.E., Hilpert, K.F., Griel, A.E., Etherton, T.D. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med. 30;113 Suppl 9B:71S-88S, 2002.
  8. 허(1977): 동의보감. 남선당. 603,71, 1: 1977.
  9. 사관(1975): 동양의학대사, 고문사. 1098, 1975.
  10. Patel, A.V., Rojas-Vera , J., Dacke, CG. Therapeutic constituents and actions of Rubus species. Curr Med Chem. 11:1501-1512, 2004.
  11. Kim, B.S., Park, Y.K., Kang, B.S. The effect of rubi fructus on the ovulation and ovary in rats. Kor. J. Herbology.16(1), 139-152, 2001.
  12. Lee, M.K., Lee, H.S., Choi, G.P., Oh, D.H., Kim, J.D., Yu, C.Y., Lee, H.Y. Screening of biological activities of the extracts from Rubus coreanus Miq. Korean J. Medicinal Crop Sci. 11(1):5-12, 2003.
  13. 윤진표: 복분자 전액 투여에 의한 가토의 자궁 및 난포 발육 촉진에 관한 연구. 원광대학교 대학원 한의학과 학위논문집. 443-465, 1982.
  14. Chen, K., Fang, J., Kuang, X., Mo, Q. Effects of the fruit of Rubus chingii on hypothalamus-pituitary-sex gland axis in rats. Zhongguo Zhong Yao Za Zhi. 21(9): 560-562, 1996.
  15. 백병걸, 임채웅, 이은영, 황인수, 권혁년, 이희곤, 이성일, 이형자, 전병훈: 복분자 술이 흰쥐의 testosterone 분비에 미치는 영향. 동의생리병리학회지. 18(4):1007-1013, 2004.
  16. 진존인: 한방의학대사전. 동도출판사. 356-359, 1984.
  17. Yoon, I., Cho, J.Y., Kuk, J.H., Wee, J.H., Jand, M.Y., Ahn, T.H., Park, K.H. Identification and activity of antioxidative compounds from Rubus coreanum fruit. Korean J. Food Sci. Technol. 34(5):898-904, 2002.
  18. Choi, J.W., Lee, K.T., Ha, J.H., Yun, S.Y., Ko, C.D., Jung, H.J., Park, H.J. Antinociceptive and antiinflammatory effects of niga-ichigoside F1 and 23-hydroxytormentic acid obtained from Rubus coreanus. Biol. Pharm. Bull. 26(10):1436-1441, 2003.
  19. Oerter, K.K., Janfaza, M., Wong, J.A., Chang, R.J. Estrogen bioactivity in fo-ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. J Clin Endocrinol Metab. 88(9):4077-4079, 2003.
  20. Bigler, D., Guiding, K.M., Dann, R., Sheabar, F.Z., Conaway, M.R., Theodorescu, D. Gene profiling and promoter reporter assays: novel tools for comparing the biological effects of botanical extracts on human prostate cancer cells and understanding their mechanisms of action. Oncogene. 27; 22(8):1261-1272, 2003.
  21. Moyer, R.A., Hummer, K.E., Finn, CE. , Frei, B., Wrolstad, R.E. Anthocyanins phenolics, and antioxidant capacity indiverse small fruits: vaccinium, rubus, and ribes. J Agric Food Chem. 50, 519-525, 2002.
  22. Moon, G.S. Constituents and Uses of medicinal Herbs. Ilweolseogak. 310-311, 1991.
  23. 김호철: 복분자류의 효능에 관한 비교 연구. 경희대학교 대학원 석사학위논문. 16; 1989.