Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Healing Effects of Astragali Radix Extracts on Experimental Open Wounds in Rats

흰쥐의 외과적 창상에 대한 황기(黃耆) 추출액의 치료효과

  • Han, Dong-Oh (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Kim, Gun-Ho (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Choi, Yong-Bok (Bio Research Team, Central Research Institute, Hyosung Co.) ;
  • Shim, In-Sop (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee, Hye-Jung (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Lee, Yong-Gheun (Department of Oriental Pediatrics, Bundang Oriental Hospital, Dongguk University) ;
  • Kim, Jang-Hyun (Department of Oriental Pediatrics, Bundang Oriental Hospital, Dongguk University) ;
  • Chang, Gyu-Tae (Department of Oriental Pediatrics, Bundang Oriental Hospital, Dongguk University) ;
  • Hahm, Dae-Hyun (Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • 한동오 (경희대학교 동서의학대학원 동서의학과) ;
  • 김건호 (경희대학교 동서의학대학원 동서의학과) ;
  • 최용복 ((주)효성 중앙연구소 BIO연구팀) ;
  • 심인섭 (경희대학교 동서의학대학원 동서의학과) ;
  • 이혜정 (경희대학교 동서의학대학원 동서의학과) ;
  • 이용근 (동국대학교 분당한방병원 한방소아과학교실) ;
  • 김장현 (동국대학교 분당한방병원 한방소아과학교실) ;
  • 장규태 (동국대학교 분당한방병원 한방소아과학교실) ;
  • 함대현 (경희대학교 동서의학대학원 동서의학과)
  • Published : 2005.02.25
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Abstract

Inhibition of inflammatory response, acceleration of basal cell growth, and balanced synthesis of extracellular matrix (ECM) are important in healing of cutaneous open wounds. In order to evaluate the healing effects of water extracts of Radix Astragali (the root of Astragalus membranaceus (Fisch.)) on open wound at early stage, the experimental open wounds were generated on the dorsal sides of SD rats under anesthesia. The boiled-water extracts of Radix Astragali $(100{\mu}l)$, soaked into an occlusive film dressing were applied once a day for eleven consecutive days. The healing process was assessed by measuring macroscopic appearance and wound areas of the open wounds. The molecular aspects of healing process by Radix Astragali extracts were also investigated by Hematoxylin-Eosin (H-E) double staining and immunohistological staining of collagen type I in the healed skin area, implying cell density and linear alignment of the granulation tissue, and ECM synthesis and its remodeling, respectively. The Astragali radix extracts were found to significantly accelerate the cutaneous wound healing by suppressing the inflammation and stimulating the basal cell growth in wounded area, as compared to epidermal growth factor (EGF).

Keywords

References

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