Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Effect of $Angelica^{(R)}$ against Skin Photo-aging

$Angelica^{(R)}$의 피부 광노화에 대한 효과

  • Published : 2005.09.30
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Abstract

Skin aging is not a disease nor an abnormal phenomenon but a collection of degenerative changes with age, characterized by skin dryness, wrinkle formation, and loss of skin elasticity. The skin wrinkles are caused by either genetically predisposed factors or environmental factors such as UV irradiation or physical/chemical stimulus. The histological manifestations of wrinkles are changes in both amount and integrity of elastic and collagen fibers. Here we report the isolation and characterization of 3 active compounds, prangenidin, 8-hydroxybergapten, and xanthotoxol from Angelica dahurica root. The anti-wrinkle activities of these compounds were also investigated.

피부노화는 피부의 이상현상이나 질환은 아니며 나이가 들어감에 따라 시간의 진행에 따라 일어나는 퇴행성 변화로 외적형태의 변화로는 피부 건조 및 주름 등이 있다. 주름을 생성하는 원인에는 자외선, 건조 및 물리적, 화학적 자극 등 환경요인에 기인하는 피부 스트레스와 각질층의 수분량 저하, 비후화, 진피의 교원섬유, 탄력섬유의 양적, 질적 변화 등이 유발하는 피부의 탄력성이나 신축성의 저하를 들 수 있다. 본 연구에서는 Angelim dahurica root에서 얻어진 3종의 주름개선 유효성분의 구조분석 및 피부 노화에 대한 효과를 살펴보았다.

Keywords

References

  1. S. P. Jerome, L. Gabrielle, and F. Raul, Identification of collagen fibrils in scleroderma skin, J. Invest. Dermatol., 90(1), 48 (1998) https://doi.org/10.1111/1523-1747.ep12462561
  2. K. Balin and A. M Kligman, Aging and skin, Raven press (1989)
  3. El-Domyati M, S. Attia, F. Saleh, D. Brown, D. E. Birk, F. Gasparro, H. Ahmad, and J. Uitto, Intrinsic aging vs. photoaging, a comparative histopathological, immunohistochemical, and ultrastructural study of skin, Exp. Dermatol., 11(5), 398 (2002) https://doi.org/10.1034/j.1600-0625.2002.110502.x
  4. P. U. Giacomoni and G. Rein, Factors of skin ageing share common mechanisms, Biogerontology, 2(4), 219 (2001) https://doi.org/10.1023/A:1010000816277
  5. M. Wlaschek, I. Tantcheva-Poor, L. Naderi, Ma W, Schneider LA, Razi-Wolf Z, J, Schuller, and K. Scharffetter- Kochanek, Solar UV irradiation and dermal photoaging, J. Photochem Photobiol. B. 63(1), 41 (2001) https://doi.org/10.1016/S1011-1344(01)00201-9
  6. F. Bonte, M. Dumas, C. Chaudagne, and A. Meybeck, Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis, Planta Med., 60(2), 133 (1994)
  7. 중약대사전(中) 상해과학기술 출판사 (1997)
  8. 장일무, 동양의약과학대전 I. 학술편수관 (2003)
  9. A. Oikarinen, P. Autio, U. Kiistala, L. Risteli, and J. Risteli, A new method to measure type I and III collagen synthesis in human skin in vivo: Demonstration of decreased collagen synthesis after topical glucocorticoid creatment, J. Invest. Dermatol., 98(2), 220 (1992) https://doi.org/10.1111/1523-1747.ep12555884
  10. J. K. Jutley, E. J. Wood, and W. J. Cunliffe, Influence of retinoic acid and TGF-b on dermal fibroblast proliferation and collagen production in monolayer cultures and dermal equivalents, Matrix, 13, 235 (1993) https://doi.org/10.1016/S0934-8832(11)80007-7
  11. N. P. Singh, Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis, Mutat Res., 455, 111 (2000) https://doi.org/10.1016/S0027-5107(00)00075-0
  12. K. Konca, A. Lankoff, A. Banasik, H. Lisowska, T. Kuszewski, S. Gozdz, Z. Koza, and A. Wojcik, A cross-platform public domain PC image-analysis program for the comet assay, Mutat Res., 534, 15 (2003) https://doi.org/10.1016/S1383-5718(02)00251-6
  13. M. Junichi, I. Takeshi, M. Nakahara, and K. Hiroshi, Cosmetics containing xanthoxol-skin lightening, JP 99- 316450 (1999)
  14. Y. I. Khadzhai, G. V. Obolentseva, and A. P. Prokopenko, Relation between structure and spasmolytic activity in coumarin and furocoumarin derivatives, Sci. -Res. Chem. - Pharm. Inst., 29(2), 156 (1966)