Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Structures and Biological Activities of Novel Antibiotic Peptaibols Neoatroviridins A-D from Trichoderma atroviride F80317

  • OH SEUNG UK (Korea Research Institute of Bioscience and Biotechnology) ;
  • YUN BONG SIK (Korea Research Institute of Bioscience and Biotechnology) ;
  • LEE SANG JUN (Pharmaceutical and Health Research Institute, Pacific Corporation) ;
  • YOO ICK DONG (Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2005.04.01
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Abstract

Four new antibiotic peptaibols, named neoatroviridins A (1), B (2), C (3), and D (4), have been isolated from the culture broth of Trichoderma atroviride. Their amino acid sequences were determined mainly by mass spectrometry in combination with NMR studies. The absolute stereochemistry of neoatroviridins was established as L by GC analysis of their acid hydrolysates with derivatization, except for isovaline which was in D. Neoatroviridins, composed of 18 amino acid residues, showed significant membrane-perturbing activity responsible for their antibiotic action, which was comparable to that of alamethicin, a well-known 20-residue peptaibol.

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References

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