Archives of Pharmacal Research

  • 제28권3호
  • /
  • Pages.285-289
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  • 2005
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

New Cytotoxic Sulfated Saponins from the Starfish Certonardoa semiregularis

  • Wang Wei Hong (College of Pharmacy, Pusan National University) ;
  • Jang Hyo Jin (College of Pharmacy, Pusan National University) ;
  • Hong Jong Ki (Basic Science Institute) ;
  • Lee Chong Ok (Korea Research Institute of Chemical Technology) ;
  • Bae Song Ja (Silla University) ;
  • Shin Sook (Sahmyook University) ;
  • Jung Jee H. (College of Pharmacy, Pusan National University)
  • 발행 : 2005.03.01
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초록

Two new sulfated saponins designated as certonardosides P$_{2}$ and I$_{3}$ (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.

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참고문헌

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