Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Primary Signet Ring Cell Carcinoma of the Lung: A Case Report

원발성 반지세포 폐암종 1예

  • Cho, Joo Yeon (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Lee, Hyun-Kyung (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Lee, Sung Soon (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Lee, Young Min (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Jin, Jae Yong (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Lee, Hyuk Pyo (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Kim, Joo In (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Choi, Soo Jeon (Department of Internal Medicine, Inje University, College of Medicine) ;
  • Kang, Yun Kyung (Department of Pathology, Inje University, College of Medicine) ;
  • Ro, Jae Yoon (Department of Pathology, University of Ulsan, College of Medicine, Asan Medical Center) ;
  • Yum, Ho-Kee (Department of Internal Medicine, Inje University, College of Medicine)
  • 조주연 (인제대학교 서울백병원 내과학교실) ;
  • 이현경 (인제대학교 서울백병원 내과학교실) ;
  • 이성순 (인제대학교 서울백병원 내과학교실) ;
  • 이영민 (인제대학교 서울백병원 내과학교실) ;
  • 진재용 (인제대학교 서울백병원 내과학교실) ;
  • 이혁표 (인제대학교 서울백병원 내과학교실) ;
  • 김주인 (인제대학교 서울백병원 내과학교실) ;
  • 최수전 (인제대학교 서울백병원 내과학교실) ;
  • 강윤경 (인제대학교 서울백병원 병리학교실) ;
  • 노재윤 (울산대학교 의과대학 아산병원 병리학교실) ;
  • 염호기 (인제대학교 서울백병원 내과학교실)
  • Received : 2004.04.08
  • Accepted : 2004.08.24
  • Published : 2004.11.30
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Abstract

Signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma. Because the majority of SRCCs in the lung are metastatic tumors from stomach, colon, or breast. The differential diagnosis of primary SRCC from metastatic SRCC is important but may be problematic. Recently, immunohistochemical studies are known to be valuable in determining primary sites of SRCC. Herein, we present a case of primary signet ring cell carcinoma of the lung in a 67-year-old man. Even though radiographic findings of our case were more suggestive of metastatic orgin of SRCC in the lung, we could finally conclude that lung was the primary site of SRCC with the help of immunohistochemical studies (positive TTF-1 and CK7, and negative CK 20) and other diagnostic work up.

폐의 원발성 반지세포암종은 전이성 반지세포암종 보다는 매우 드문 질환이다. 저자들은 면역조직염색법의 도움을 받아 원발성 반지세포 폐암종으로 진단된 1례를 경험하였기에 문헐고찰과 함께 보고한다. 본 증례를 통하여 반지세포암종이 폐에서 관찰되었을 때 폐 외에 원발부위가 없다면 원발성 반지세포 폐암종일 가능성을 의심하고 TTF-1 과 CK7 및 CK20 면역염색을 시행하면 진단에 도움을 받을 수 있다.

Keywords

References

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