Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
권호 표지

A Case of Isoniazid Induced Acute Pancreatitis

Isoniazid에 의해 유발된 급성 췌장염 1예

  • Chung, Byung Ha (Department of Internal Medicine, The Catholic University of Korea) ;
  • Nam, Hae Seong (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kwon, Jung Hyun (Department of Internal Medicine, The Catholic University of Korea) ;
  • Im, So Hi (Department of Internal Medicine, The Catholic University of Korea) ;
  • Park, Sun Hee (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim, Jin Woo (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim, Seung Joon (Department of Internal Medicine, The Catholic University of Korea) ;
  • Lee, Sook Young (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim, Young Kyoon (Department of Internal Medicine, The Catholic University of Korea) ;
  • Park, Sung Hak (Department of Internal Medicine, The Catholic University of Korea)
  • 정병하 (가톨릭대학교 의과대학 내과학교실) ;
  • 남해성 (가톨릭대학교 의과대학 내과학교실) ;
  • 권정현 (가톨릭대학교 의과대학 내과학교실) ;
  • 임소희 (가톨릭대학교 의과대학 내과학교실) ;
  • 박선희 (가톨릭대학교 의과대학 내과학교실) ;
  • 김진우 (가톨릭대학교 의과대학 내과학교실) ;
  • 김승준 (가톨릭대학교 의과대학 내과학교실) ;
  • 이숙영 (가톨릭대학교 의과대학 내과학교실) ;
  • 김영균 (가톨릭대학교 의과대학 내과학교실) ;
  • 박성학 (가톨릭대학교 의과대학 내과학교실)
  • Published : 2004.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Isoniazid is a first-line drug in the treatment of tuberculosis. A variety of adverse reactions of isoniazid have been reported. These include hepatitis, peripheral neuropathy, skin rashes, neurologic disturbances and hematologic alterations. Among these, acute pancreatitis due to isoniazid is very rare. We report a case of acute pancreatitis due to isoniazid confirmed by rechallenge test with review of some literatures.

본 증례는 결핵 치료 중 급성 췌장염이 발생하였고, 재투여 검사를 통하여 그 원인으로 isoniazid임을 확인하였다. 결핵 치료 중인 환자에서 위장관장애 증상이 있을 때, 그 원인으로서 간염이외에 급성 췌장염을 고려해 봐야 할 것이다.

Keywords

References

  1. Lankisch PG, Droge M, Gottesleben F. Drug induced acute pancreatitis: incidence and severity. Gut 1995;37:565-7
  2. Mallory A, Kern F Jr. Drug induced pancreatitis: A critical review. Gastroenterology 1980;78:813-20
  3. Mattson K. Side effects of rifampicin. A clinical study. Scand J Respir Dis Suppl1973;82:1-52
  4. Chan TY. Isoniazid and rifampicin rarely cause acute pancreatitis in patients withtuberculosis. Int J Clin Pharmacol Ther 1999; 37:109
  5. Rabassa A, Trey G, Shukla U, Samo T, Anand BS. Isoniazid induced acute pancreatitis. Ann Intern Med 1994;121:433-4
  6. Davidson PT, Le HQ. Drug treatment of tuberculosis-1992. Drugs 1992;43:651-73
  7. Goldman AL, Braman SS. Isoniazid: a review with emphasis on adverse effects. Chest 1972;62:71-7
  8. Izzedine H, Launay-Vacher V, Storme T, Deray G. Acute pancreatitis induced byisoniazid. Am J Gastroenterol 2001;96:3208-9.
  9. Chan KL. Chan HS, Lui SF. Lai KN. Recurrent acute pancreatitis induced byisoniazid. Tuber Lung Dis 1994;75:383-5
  10. Stephenson I, Wiselka MJ, Qualie MJ. Acute pancreatitis induced by isoniazid in the treatment of tuberculosis. Am J Gastroenterol 2001;96:2271-2
  11. Mendoza JL, Larrubia JR, Lana R, Espinos D, Diaz-Rubio M. Acute pancreatitis induced by isoniazid, a casual association. An Med Interna 1998;15:588-90