A Case of Paragonimiasis in the Abdominal Subcutaneous Tissue with Pleural Effusion

흉막 삼출을 동반한 복부 피하 지방 조직의 폐흡충증 이소기생 1례

  • Im, So Hi (Department of Internal Medicine, The Catholic University of Korea) ;
  • Shin, Sung Hwan (Department of Internal Medicine, The Catholic University of Korea) ;
  • Song, Myung Jun (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim, Jin Woo (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim, Seung Joon (Department of Internal Medicine, The Catholic University of Korea) ;
  • Lee, Sook Young (Department of Internal Medicine, The Catholic University of Korea) ;
  • Kim, Young Kyoon (Department of Internal Medicine, The Catholic University of Korea) ;
  • Park, Sung Hak (Department of Internal Medicine, The Catholic University of Korea)
  • 임소희 (가톨릭대학교 의과대학 내과학교실) ;
  • 신승환 (가톨릭대학교 의과대학 내과학교실) ;
  • 송명준 (가톨릭대학교 의과대학 내과학교실) ;
  • 김진우 (가톨릭대학교 의과대학 내과학교실) ;
  • 김승준 (가톨릭대학교 의과대학 내과학교실) ;
  • 이숙영 (가톨릭대학교 의과대학 내과학교실) ;
  • 김영균 (가톨릭대학교 의과대학 내과학교실) ;
  • 박성학 (가톨릭대학교 의과대학 내과학교실)
  • Published : 2004.05.30

Abstract

A paragonimiasis infestation is caused by the paragonimus species. It is commonly found in the lung but has also been found to exist extrapulmonary infestations including cerebral, spinal, subcutaneous, hepatic, splenic, abdominal, urinary, and gynecologic infestation. On the other hand, a cutaneous infestation is extremely rare. Human infestation is caused by ingesting raw or undercooked intermediate hosts. Because paragonimus westermani larva mature to an adult worm in the lung, the possibility of identifying the adult worm of paragonimus westermani at extrapulmonary region is very rare. Case : After ingesting a fresh-water crab 1 month prior to the hospital visit, a 45-year old female patient was suffering from right pleuritic chest pain during that 1 month. The patient also complained of a palpable mass that was movable and migrating, and it was localized at the right upper quadrant of the abdomen. The eosinophil fraction of the white blood cell of peripheral blood and pleural fluid was elevated to 55.1% and 90%, respectively. Parasite eggs were not found in her sputum and stool examination. By using the enzyme-linked immunosorbent assay (ELISA), the paragonimus-specific IgG antibody titer was elevated to 0.28. During incisional biopsy, we were able to find the young adult worm of paragonimus westermani. We experienced the rare case of ectopic paragonimiasis with pleural effusion that was confirmed by identifying the adult worm of paragonimus westermani within the abdominal subcutaneous tissue. We report a case with brief literature reviews.

과거에 비해 최근에는 우리나라에서 기생충 감염의 빈도가 낮아지긴 하였지만, 우리나라에서 비교적 흔한 감염원인 민물 게장등을 섭취한 병력이 있고, 호산구성 흉막 삼출과 말초혈액에서 호산구증다증이 있을 경우, 반드시 기생충 감염의 가능성을 생각해 보아야 한다. 피하조직에서의 폐흡충의 이소기생 례가 빈번한 것은 아니지만, 본 증례와 같이 이동성의 복부 종괴가 있을 경우 조직검사와 면역학적 검사를 통해 기생충 감염 여부에 대한 확인 절차는 반드시 필요하다. 그럼으로써, 결핵이나 폐암등 다른 질환으로의 오진에 의해 발생하는 경제사회적 손실을 최소화할 수 있을 것으로 사료된다.

Keywords

References

  1. 최동익. Paragonimus and paragonimiasis in Korea. 대한기생충학잡지 1990;28:79-102
  2. Kim DC. Paragonimus westermani:life cycle, intermediate hosts, transmission to man and geographical distribution in Korea. Arzneimit-telforschung 1984;34(9B):1180-3
  3. 이순형, 채종일, 홍성태. 흡충류. 기생충학 개요. 서울: 고려의학; 1996. p. 207-15
  4. Kagawa FT. Pulmonary paragonimiasis. Se-min Respir Infect 1997;12(2):149-58
  5. 최진원, 박익수, 신동호, 박성수, 이정희. 폐흡충증 환자의 임상적 고찰. 결핵 및 호흡기질환 1993;40(3):274-82
  6. Nakamura-Uchiyama F, Mukae H, Nawa Y. Paragonimiasis:a Japanese perspective. Clin Chest Med 2002;23(2):409-20
  7. 최원영, 정상설. 복부 피하 지방 조직의 폐흡충증 이소기생례. 기생충학잡지 1991;29(4):407-9
  8. Mizuki M, Mitoh K, Miyazaki E, Tsuda T. A case of Paragonimiasis westermani with pleural effusion eight months after migrating subcutaneous induration of the abdominal wall. Nihon Kyobu Shikkan Gakkai Zasshi 1992;30(6):1125-30
  9. 이응석, 하승연, 조현이, 김한겸, 배정원, 김인선, 유방에 발생한 이소성 폐흡충증, 대한병리학회지 1993;27:656-8
  10. Matsumoto T, Kimura S, Yamauchi M, Nawa Y, Miike T. Soluble CD23 and IL-5 levels in the serum and culture supernatants of peripheral blood mononuclear cells in a girl with cutaneous paragonimiasis: case report. Ann Trop Paediatr 1998;18(1):49-53
  11. Hatano Y, Katagiri K, Ise T, Yamaguchi T, Itami S, Nawa Y, et al. Expression of Th1 and Th2 cytokine mRNAs in freshly isolated peripheral blood mononuclear cells of a patient with cutaneous paragonimiasis. J Dermatol Sci 1999;19:144-7
  12. Ashitani J, Kumamoto K, Matsukura S. Para-gonimiasis westermani with multifocal lesi-ons in lungs and skin. Intern Med 2000;39(5):433-6
  13. Takemasa H, Saito K, Nakayamada S, Kana-zawa T, Tanaka Y. A case of Paragoni-miasis westermanii complicated with migra-ting subcutaneous induration and multiple involvements in the liver. Kansenshogaku Zasshi 2002;76(8):594-9
  14. Dainichi T, Nakahara T, Moroi Y, Urabe K, Koga T, Tanaka M, et al. A case of cutane-ous paragonimiasis with pleural effusion. Int J Dermatol 2003;42:699-702
  15. Jun SY, Jang J, Ahn SH, Park JM, Gong G. Paragonimiasis of the breast. Report of a case diagnosed by fine needle aspiration. Acta Cytol 2003;47(4):685-7