사상체질의학회지 (Journal of Sasang Constitutional Medicine)
- 제16권2호
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- Pages.84-98
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- 2004
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- 1226-4075(pISSN)
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- 2287-786X(eISSN)
양격산화탕(凉膈散火湯)이 Atopy 피부염(皮膚炎)에 미치는 영향(影響)
Yangkyuksanhwa-tang effected to Atopic Dermatitis
- Yun, Bo-Hyun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dongguk Univ.) ;
- Park, Seong-Sik (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Dongguk Univ.)
- 투고 : 2004.07.09
- 심사 : 2004.08.04
- 발행 : 2004.08.01
초록
1. Objectives Yangkyuksanhwa-tang is used mush in pruritus and dermatopathy of Soyangin. It is suggested this prescription is effective on atopy dermatitis. 2. Methods For observation of Yangkyuksanhwa-tang effected to atopic dermatitis, extract of Yangkyuksanhwa-tang has been dispensed to the stratum corneum of epithelium in dermatome of murine after making damage to its defense mechanism against fat and causing atopic dermatitis artificially. After that, the change in outer dermatome and minute mechanism of epidermis, the change of eosinophil, the change in distribution of soybean agglutinin, the change in distribution of fat and ceramide in stratum corneum, the change in inflammation in dermatome, the change of cell accrementition and apoptosis, and the effect on anaphylaxis and Staphylococcus aureus was observed. 3. Results After administration of Yangkyuksanhwa-tang, severe skin damage such as eczema and psoriasis, that was observed in the case of atopy dermatitis, was decreased and the increase of eosinophil in serum was suppressed. Lipid lamella was recovered, so epidermal demage was relieved. The distribution of HSP70 in the outer skin was decreased. Yangkyuksanhwa-tang suppressed activation of
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