사상체질의학회지 (Journal of Sasang Constitutional Medicine)

  • 제16권1호
  • /
  • Pages.130-147
  • /
  • 2004
  • /
  • 1226-4075(pISSN)
  • /
  • 2287-786X(eISSN)
사상체질의학회 (The Society Of Sasang Constitutional Medicine)
권호 표지

청심연자탕(淸心蓮子湯)의 항산화(抗酸化) 효과(效果)와 기전(機轉)에 관한 연구(硏究)

Antioxidant effects and its mechanism of Cheongsimyeonjatang in Sasang Constitutional Medicine

  • 한병삼 (원광대학교 사상체질의학과) ;
  • 배영춘 (원광대학교 사상체질의학과) ;
  • 송승연 (원광대학교 사상체질의학과) ;
  • 박혜선 (원광대학교 사상체질의학과) ;
  • 이재흥 (원광대학교 사상체질의학과) ;
  • 김경요 (원광대학교 사상체질의학과)
  • Han, Byeung-Sam (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Bae, Young-Chun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Song, Seung-Yun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Park, Hye Sun (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Lee, Jae-Heung (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.) ;
  • Kim, Kyung-Yo (Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Wonkwang Univ.)
  • 투고 : 2004.03.24
  • 심사 : 2004.04.15
  • 발행 : 2004.04.01
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초록

To investigate the antioxidant capacity of traditional Korean herb medicines, water extracts from 42 species which has been used for the Taeum constitution of Sasang Medicine, were tested on their antioxidant activity using radical scavenging effects against ABTS. Some Of them showed strong antioxidant capacities at $50{\mu}g$ concentration. And, antioxidant capacities of 2 prescriptions extract of Sasang Medicine, Cheongsimyeonja-tang and Yeoldahanso-tang, in the different concentration ($10{\mu}g$, $50{\mu}g$, and $100{\mu}g$) were determined. At the same time, the antiperoxidation effects of these 2 prescriptions extract were determined. Lipid peroxidation in brain homogenates induced by NADPH and $ADF-Fe^{2+}$ was strongly inhibited by Cheongsimyeonja-tang in vitro. The above-mentioned 2 prescriptions are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders in brain tissue.

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