Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Primary Signet Ring Cell Carcinoma of Lung with Multiple Bone Metastasis

다발성 골전이를 동반한 진행된 원발성 반지세포 폐암종(Primary Signet Ring Cell Carcinoma of Lung) 1예

  • Shin, Do Hyun (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Kim, Hyoung Il (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Lim, Seon-Kyo (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Lee, Seung Won (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Jung, Youn Mu (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Choi, Young In (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Sheen, Seung Soo (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Park, Joo Hun (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Oh, Yoon Jung (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Park, Kwang Joo (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Hwang, Sung Chul (Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine) ;
  • Park, Rae Woong (Department of Pathology, Ajou University School of Medicine) ;
  • Chul, Shim (Department of Pathology, Ajou University School of Medicine)
  • 신도현 (아주대학교 의과대학 호흡기내과학교실) ;
  • 김형일 (아주대학교 의과대학 호흡기내과학교실) ;
  • 임선교 (아주대학교 의과대학 호흡기내과학교실) ;
  • 이승원 (아주대학교 의과대학 호흡기내과학교실) ;
  • 정연무 (아주대학교 의과대학 호흡기내과학교실) ;
  • 최영인 (아주대학교 의과대학 호흡기내과학교실) ;
  • 신승수 (아주대학교 의과대학 호흡기내과학교실) ;
  • 박주헌 (아주대학교 의과대학 호흡기내과학교실) ;
  • 오윤정 (아주대학교 의과대학 호흡기내과학교실) ;
  • 박광주 (아주대학교 의과대학 호흡기내과학교실) ;
  • 황성철 (아주대학교 의과대학 호흡기내과학교실) ;
  • 박래웅 (아주대학교 의과대학 병리학교실) ;
  • 심철 (아주대학교 의과대학 병리학교실)
  • Received : 2004.08.30
  • Accepted : 2004.09.21
  • Published : 2004.12.30
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Abstract

Signet ring cell carcinoma of lung is an unique variant of mucin producing adenocarcinoma which is characterized by abundant intracellular mucin accumulation. Only a few cases of primary signet ring cell carcinoma of lung have been reported in the world wide literature. And we have, recently experienced one case of primary signet ring cell carcinoma of lung. A 55 years old man was evaluated for paralysis of lower extremities and was found to have lung cancer in the left upper and lower lobe with pleural, multiple spinal, bone and liver metastases. Signet ring tumor cells were revealed by cytologic examination of pleural fluids. And there were no evidence of signet ring cell carcinoma of other organs. Primary signet ring cell carcinoma of lung seems to have an aggressive behavior and therapeutic modalities could be different from those for signet ring cell carcinomas from other organs. Therefore it is important to separate primary signet ring cell adenocarcinoma of lung from metastatic tumors.

원발성 반지세포 폐암종은 점액을 분비하는 독특한 선암의 일종으로 매우 드물게 발생한다. 예후가 불량하므로 타 원발성 및 전이성 폐암종과 감별이 필요하고 임상적인 검사로 원발병소를 찾기가 어려울 경우 조직면역학적 방법이 감별에 도움이 된다. 본 저자들은 다발전 골전이를 동반한 진행된 원발성 반지세포 폐암종의 증례를 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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