Journal of Haehwa Medicine (혜화의학회지)

Research Institute of Korean Medicine (대전대학교 한의학연구소)
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Study on the Effect of SGHHT on Hyperlipidemia

순기활혈탕(順氣活血湯)이 고지혈증(高脂血症)에 미치는 영향(影響)

  • Lee, Ki-Seo (Dept. of Pharmacology, Collage of Oriental Medicine, Daejeon Univ.) ;
  • Kang, Tak-Lim (Dept. of Pharmacology, Collage of Oriental Medicine, Daejeon Univ.) ;
  • Namgung, Uk (Dept. of Neurophysiology, Collage of Oriental Medicine, Daejeon Univ.) ;
  • Kim, Dong-Hee (Dept. of Pathology, Collage of Oriental Medicine, Daejeon Univ.)
  • 이기서 (대전대학교 한의과대학 약리학교실) ;
  • 강탁림 (대전대학교 한의과대학 약리학교실) ;
  • 남궁욱 (대전대학교 신경생리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실)
  • Accepted : 2004.10.14
  • Published : 2004.12.30
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Abstract

As a long-term goal for the development of new prescriptions for hyperlipidemia, SGHHT was examined in the present study using a rat model in which the hyperlipidemia was induced. The major parameters related to lipid metabolism were investigated and the key findings are summarized below. 1. The body weight of hyperlipidemia-induced rats began to show lower body weight beginning one week after SGHHT treatment compared to non-treated control group animals. 2. Cholesterol levels showed a significant decrease beginning three weeks after SGHHT treatment, compared to hyperlipidemia-induced control group. 3. Total cholesterol levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 4. Glucose levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group. 5. Triglyceride levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group.6. SGOT levels in SGHHT-treated animal group were significantly decreased compared to the hyperlipidemia-induced control group whereas there was no significant change in SGPT levels. 7. HDL-cholesterol levels were significantly increased in SGHHT- treated animal group compared to the hyperlipidemia-induced control group. 8. LDL-cholesterol levels were significantly decreased in SGHHT-treated animal group compared to the hyperlidemia-induced control group.

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