Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 36 Issue 2
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- Pages.245-251
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- 2004
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
A Safety Experiment in Rats Exposed to BM-solution
BM-solution에 노출된 Rat의 안전성에 관한 조사
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Kim, Dong Kyu
(College of Veterinary Medicine, Chungbuk National University) ;
- Kim, Kee Hyun (Biomist Technology Co., LTD.) ;
- Lee, Nam Jin (College of Veterinary Medicine, Chungbuk National University) ;
- Park, Jong Bae (Department of Biology and Institute of Traditional Medicine & Biosctence, Daejeon University) ;
- Cho, Jung Hee (College of Veterinary Medicine, Chungbuk National University) ;
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Kim, Yun Bae
(College of Veterinary Medicine, Chungbuk National University) ;
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Kang, Jong Koo
(College of Veterinary Medicine, Chungbuk National University) ;
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Kim, Young Kwon
(Department of Clinical Laboratory Science, Gimcheon, College) ;
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Hwang, Seock-Yeon
(Department of Laboratory Medicine, Chungbuk National University)
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김동규
(충북대학교 수의과대학) ;
- 김기현 (바이오미스트테크놀로지) ;
- 이남진 (충북대학교 수의과대학) ;
- 박종배 (대전대학교 생물학과 및 동서생명과학연구원) ;
- 조정희 (충북대학교 수의과대학) ;
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김윤배
(충북대학교 수의과대학) ;
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강종구
(충북대학교 수의과대학) ;
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김영권
(김천대학 임상병리과) ;
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황석연
(충북대학교병원 진단검사의학과)
- Published : 2004.12.31
Abstract
This study was experiment on the safety of rat(Sprague-Dawley) exposed to natural herb oil(BM-solution). BM-solution was administered by inhalation to rats with the dose level of low(30 mg/8 min), middle(30 mg/4 min) and high(50 mg/4 min) in an airtight room for 4 weeks, respectively. Each groups, consisting of 5 rats, was examined for body weight changes, hematological analysis, serum biochemical analysis, organ weight, and histopathological findings, respectively. There were, dose-dependently, no changes of body weight and organ weights, no hematological anomalousness, and no other serum biochemical abnormality from the experiments. In addition, BM-solution was shown to have no specific toxicity by gross and histopathological findings. Therefore, it was concluded that BM-solution had no side effects on rats for 4 weeks.