광주기독병원 30년간 세포유전학적 검사결과의 고찰

Analysis of Cytogenetics Diagnosis: form 30 Years Experience at Kwangju Christian Hospital

  • 김윤식 (광주기독병원 시험관아기실 및 세포유전학실) ;
  • 기원진 (광주기독병원 진단검사의학과) ;
  • 백해경 (광주기독병원 진단검사의학과) ;
  • 이상호 (광주기독병원 진단검사의학과) ;
  • 신진호 (광주기독병원 진단검사의학과)
  • Kim, Yoon Sik (Department of Cytogenetics & In Vitro Fertilization Division, Kwangju Christian Hospital) ;
  • Kee, Won Jin (Department of Laboratory Medicine, Kwangju Christian Hospital) ;
  • Back, Hae Kyong (Department of Laboratory Medicine, Kwangju Christian Hospital) ;
  • Lee, Sang Ho (Department of Laboratory Medicine, Kwangju Christian Hospital) ;
  • Shin, Jin Ho (Department of Laboratory Medicine, Kwangju Christian Hospital)
  • 발행 : 2004.12.31

초록

This study was carried out to review and evaluate a total of 2,463 cases of human chromosomal analysis at Kwangju Christian Hospital from 1974 to 2004. We collected 2.0-3.0ml of human peripheral blood in heparized bottle. Then, we cultured it for 72 hours. We performed GTG-banding and chromosomal kayotyping analysis by Cytovision kayotyping system. Abnormal karyotypes were observed in 30.5% of the total cases (750/2,463). Autosome and sex chromosome anomalies were observed in 25.8% (635/2,463) and 4.7% (115/2,463) respectively. In a total of 2463 cases, there were 522 (22.4%) cases of Down's syndrome karyotype, and 67 (2.7%) cases of Turner syndrome. In conclusion, Down's syndrome has decreased after the end of the 1990s, but other (Turner syndrome et al.) chromosomal abnormal cases haven't decreased after the1970s.

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