대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)

  • 제36권1호
  • /
  • Pages.49-54
  • /
  • 2004
  • /
  • 1738-3544(pISSN)
  • /
  • 2288-1662(eISSN)
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)
권호 표지

고지혈증 랫드에서 구기자 추출물이 혈중 지질에 미치는 영향

Changes of Serum Lipid after Treatement of Lycii fructus Extract in Hyperlipemia Rats

  • 조정희 (충북대학교 수의과대학) ;
  • 신지순 (충북대학교 수의과대학) ;
  • 배형준 (서울보건대학 임상병리과) ;
  • 김윤배 (충북대학교 수의과대학) ;
  • 강종구 (충북대학교 수의과대학) ;
  • 황석연 (충북대학교병원 진단검사의학과)
  • Cho, Jung Hee (College of Veterinary Medicine, Chungbuk National University) ;
  • Sin, Ji Soon (College of Veterinary Medicine, Chungbuk National University) ;
  • Bae, Hyung Joon (Department of Clinical Laboratory Science Seoul Health College) ;
  • Kim, Yun Bae (College of Veterinary Medicine, Chungbuk National University) ;
  • Kang, Jong Koo (College of Veterinary Medicine, Chungbuk National University) ;
  • Hwang, Seock Yeon (Department of Clinical Laboratory Medicine, Chungbuk National University)
  • 발행 : 2004.06.30
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초록

The purpose of this study was to investigate the effects of Lycii fructus extract on the serum lipids in hyperlipemia rats. The rats were divided five groups including negative control, positive control and treated L. fructus extract at dose of 50, 100, 200 mg/kg. To induce the hyperlipemia, 4 groups of rats, not including the negative control group, were fed experimental diets consisting of cholesterol, lard, corn oil, and normal diet for experiment period. As a result, the L. fructus extract decreased total cholesterol(T. Cho), trigryceride(TG), low density lipoprotein cholesterol(LDL-C), and free fatty acid(FFA) significantly compared with positive control. However, no significant difference was found in high density lipoprotein(HDL-C) and phospholipid(PPL) level. Otherwise, in serum lipid level including, T-Cho, TG, LDL-C, FFA and PPL was decreased dose dependently by treatment of L. fructus extract. But HDL-C was increased by L. fructus extract too. Thereby having beneficial effect on hyperlipermia by influencing the serum lipid change, it is expected that Lycii fructus extract can suppress arteriosclerosis and obesity.

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