동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제18권1호
  • /
  • Pages.194-199
  • /
  • 2004
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

천마반하탕이 뇌혈류역학에 미치는 영향

Effect of Cheonmabanhwa-tang on the Cerebral Hemodynamics in Rats

  • 양기호 (동신대학교 한의과대학 병리학교실) ;
  • 정현우 (동신대학교 한의과대학 병리학교실)
  • Yang Gi Ho (Department of Pathology, College of Oriental Medicine. Dongshin University) ;
  • Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine. Dongshin University)
  • 발행 : 2004.02.01
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초록

Cheonmabanhwa-tang(CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam. This study was designed to investigate whether CBT has a cytotoxicity in vitro, and affects the cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD), and mean arterial blood pressure(MABP)) in normal and cerebral ischemic rats. The changes of rCBF were determinated by laser-doppler f1owmeter(LDF), and the change of PAD was determinated by video-microscopy. The results in normal rats were as follows: CBT had no cytotoxicity in neuronal cells. CBT significantly increased rCBF. MABP and PAD in a dose-dependent manner, respectively. Both rCBF and PAD were significantly and stably increased by CBT(10 mg/kg, i.p.) during the period of cerebral reperfusion. which contrasted with the findings of rapid and marked increase in control group. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics thereby has an anti-ischemic action.

키워드

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