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Effect of Cheonmabanhwa-tang on the Cerebral Hemodynamics in Rats  

Yang Gi Ho (Department of Pathology, College of Oriental Medicine. Dongshin University)
Jeong Hyun Woo (Department of Pathology, College of Oriental Medicine. Dongshin University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.1, 2004 , pp. 194-199 More about this Journal
Abstract
Cheonmabanhwa-tang(CBT) has been used in the Oriental Medicine for many centuries as a therapeutic agent for dizziness due to Poong-Dam. This study was designed to investigate whether CBT has a cytotoxicity in vitro, and affects the cerebral hemodynamics [regional cerebral blood flow(rCBF), pial arterial diameter(PAD), and mean arterial blood pressure(MABP)) in normal and cerebral ischemic rats. The changes of rCBF were determinated by laser-doppler f1owmeter(LDF), and the change of PAD was determinated by video-microscopy. The results in normal rats were as follows: CBT had no cytotoxicity in neuronal cells. CBT significantly increased rCBF. MABP and PAD in a dose-dependent manner, respectively. Both rCBF and PAD were significantly and stably increased by CBT(10 mg/kg, i.p.) during the period of cerebral reperfusion. which contrasted with the findings of rapid and marked increase in control group. In conclusion, it is suggested that CBT causes a diverse effect on cerebral hemodynamics thereby has an anti-ischemic action.
Keywords
Cheonmabanhwa-tang(天麻半夏湯); cerebral hemodynamics; laser-doppler flowmeter; cerebral ischemia;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
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