동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제18권2호
  • /
  • Pages.586-595
  • /
  • 2004
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

Protective Effects of Kamidojuk-san on the Nervous Systems

  • Hwang Chang Ha (Department of Oriental Medicine, Daejeon University College of Oriental Medicine) ;
  • Nam Gung Uk (Neurophysiology Lab. Daejeon University College of Oriental Medicine) ;
  • Park Jong Oh (Department of Oriental Medicine, Daejeon University College of Oriental Medicine) ;
  • Lee Yong Koo (Daejeon University Oriental hospital) ;
  • Choi Sun Mi (Korea Institute of Oriental Medicine) ;
  • Kim Dong Hee (Department of Oriental Medicine, Daejeon University College of Oriental Medicine)
  • 발행 : 2004.04.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Kamidojuk-San (KDJS) is known to be effective for treating cardiovascular diseases such hypertension, and clinically applied for the treatment of cerebral palsy or stoke patients. Yet, the overall mechanisms underlying its activity at the cellular levels are not known. Using experimental animal system, we investigated whether KDJS has protective effects on cells in cardiovascular and nervous systems. KDJS was found to rescue death of cultured primary neurons induced by AMPA, NMDA and kainate as well as BSO and Fe/sup 2+/ treatments. Moreover, KDJS treatment promoted animal's recovery from coma induced by a lethal dose of KCN treatment, and improved survival in animals exposed to lethal dose of KCN. Neurological examinations further showed that KDJS reduced the time which is required for animals to respond in terms of forelimb and hindlimb movements. To examine its physiological effects on cardiovascular and nervous systems, we induced ischemic injury in hippocampal neurons and cerebral neurons by middle cerebral artery (MCA) occlusion. Histological examination revealed that KDJS significantly protected neurons from ischemic damage. Thus, the present data suggest that KDJS may play an important role in protecting cells of cardiovascular and nervous systems from external noxious stimulations.

키워드

참고문헌

  1. J Comp Neurol. v.342 no.4 Immunocytochemical localization of immunoglobulins in the rat brain: relationship to the blood-brain barrier Aihara N;Tanno H;Hall JJ;Pitts LH;Noble LJ https://doi.org/10.1002/cne.903420402
  2. Acta Neuropathol(Berl) v.94 no.2 Effect of transient focal ischemia on blood-brain barrier permeability in the rat: correlation to cell injury Albayrak S;Zhao Q;Siesjo BK;Smith ML https://doi.org/10.1007/s004010050688
  3. Rev Neurosci. v.14 no.3 On the role of somatostatin in seizure control: clues from the hippocampus Binaschi A;Bregola G;Simonato M
  4. Nature. v.361 no.6407 A synaptic model of memory: long-term potentiation in the hippocampus Bliss TV;Collingridge GL https://doi.org/10.1038/361031a0
  5. FASEB J. v.14 no.10 Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia Borlongan CV;Yamamoto M;Takei N;Kumazaki M;Ungsuparkorn C;Hida H;Sanberg PR;Nishino H https://doi.org/10.1096/fj.14.10.1307
  6. Neurosci Lett. v.21;347 no.2 Hypoxic preconditioning reduces apoptosis in a rat model of immature brain hypoxia-ischaemia Cantagrel S;Krier C;Ducrocq S;Bodard S;Payen V;Laugier J;Guilloteau D;Chalon S
  7. Science v.287 no.5457 An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy During MJ;Symes CW;Lawlor PA;Lin J;Dunning J;Fitzsimons HL;Poulsen D;Leone P;Xu R;Dicker BL;Lipski J;Young D https://doi.org/10.1126/science.287.5457.1453
  8. J Neurochem. v.67 no.4 Lazaroid treatment prevents death of cultured rat embryonic mesencephalic neurons following glutathione depletion Grasbon-Frodl EM;Andersson A;Brundin P https://doi.org/10.1046/j.1471-4159.1996.67041653.x
  9. J Cereb Blood Flow Metab. v.17 no.5 [$^3$H]L-NG-nitroarginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and type III nitric oxide synthase null mice Hara H;Ayata C;Huang PL;Waeber C;Ayata G;Fujii M;Moskowitz MA https://doi.org/10.1097/00004647-199705000-00005
  10. J Neural Transm Suppl. v.65 General aspects of neurodegeneration Jellinger KA https://doi.org/10.1007/978-3-7091-0643-3_7
  11. J Neurochem. v.74 no.6 Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells Jones DC;Gunasekar PG;Borowitz JL;Isom GE https://doi.org/10.1046/j.1471-4159.2000.0742296.x
  12. Gaiding-zengbu taiyansuiwen yanfangji(改正增補苔巖隨聞驗方集) Kim Young Gi
  13. J Neural Transm. v.104 no.6;7 Excessive iron accumulation in the brain: a possible potential risk of neurodegeneration in Parkinson's disease Lan J;Jiang DH https://doi.org/10.1007/BF01291883
  14. Proc Natl Acad Sci v.99 no.23 Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation Le DA;Wu Y;Huang Z;Matsushita K;Plesnila N;Augustinack JC;Hyman BT;Yuan J;Kuida K;Flavell RA;Moskowitz MA https://doi.org/10.1073/pnas.232473399
  15. Nature. v.24;399 no.6738 Suppl The changing landscape of ischaemic brain injury mechanisms Lee JM;Zipfel GJ;Choi DW
  16. J Neural Transm Suppl. v.43 Glutamate receptor antagonists in cerebral ischaemia McCulloch J
  17. Brain Res. v.19;657 no.1;2 N-methyl-D-aspartate receptor-mediated, prolonged afterdischarges of CA1 pyramidal cells following transient cerebral ischemia in the rat hippocampus in vivo. Miyazaki S;Katayama Y;Furuichi M;Kano T;Yoshino A;Tsubokawa T
  18. Mol Cells. v.15 no.2 Blockade of calcium entry accelerates arsenite-mediated apoptosis in rat cerebellar granule cells Namgung U;Kim DH;Lim SR;Xia Z
  19. J Neurosci. v.15;18 no.10 Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia Namura S;Zhu J;Fink K;Endres M;Srinivasan A;Tomaselli KJ;Yuan J;Moskowitz MA
  20. Nature. v.14;377 no.6545 Contrasting properties of two forms of long-term potentiation in the hippocampus Nicoll RA;Malenka RC
  21. J Neural Transm Suppl. no.58 Apoptosis as a general cell death pathway in neurodegenerative diseases Offen D;Elkon H;Melamed E
  22. J Cereb Blood Flow Metab. v.15 no.6 Long-term spatial cognitive impairment after middle cerebral artery occlusion in rats: no involvement of the hippocampus Okada M;Nakanishi H;Tamura A;Urae A;Mine K;Yamamoto K;Fujiwara M https://doi.org/10.1038/jcbfm.1995.127
  23. Trends in Neurosciences v.24 no.10 Ischemic injury and faulty gene transcripts in the brain Philip K. Liu;Robert G. Grossman;Chung Y. Hsu/and Claudia S. Robertson https://doi.org/10.1016/S0166-2236(00)01918-4
  24. Neuroscience. v.62 no.3 Glutamate-induced intracellular calcium changes and neurotoxicity in cortical neurons in vitro: effect of chemical ischemia Rajdev S;Reynolds IJ https://doi.org/10.1016/0306-4522(94)90468-5
  25. J Neurosci. v.15 no.(5 Pt 1) Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation Reynolds IJ;Hastings TG https://doi.org/10.1523/JNEUROSCI.15-05-03318.1995
  26. Neurosurgery;discussion v.42 no.1 Effect of N-methyl-D-aspartate and inhibition of neuronal nitric oxide on collateral cerebral blood flow after middle cerebral artery occlusion Robertson SC;Loftus CM https://doi.org/10.1097/00006123-199801000-00023
  27. J Neurosci. v.15;19 no.20 Neuroprotective effect of high glucose against NMDA, free radical, and oxygen- glucose deprivation through enhanced mitochondrial potentials Seo SY;Kim EY;Kim H;Gwag BJ
  28. Cell Mol Biol. v.46 no.4 Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases Shoham S;Youdim MB
  29. J Cereb Blood Flow Metab. v.16 no.6 DNA fragmentation and HSP70 protein induction in hippocampus and cortex occurs in separate neurons following permanent middle cerebral artery occlusions States BA;Honkaniemi J;Weinstein PR;Sharp FR https://doi.org/10.1097/00004647-199611000-00011
  30. Neurosci Res. v.47 no.1 Antioxidant N-acetylcysteine and AMPA/KA receptor antagonist DNQX inhibited mixed lineage kinase-3 activation following cerebral ischemia in rat hippocampus Tian H;Zhang Q;Li H;Zhang G https://doi.org/10.1016/S0168-0102(03)00186-X
  31. Annu Rev Neurosci. v.22 Autoimmunity and neurological disease: antibody modulation of synaptic transmission Whitney KD;McNamara JO https://doi.org/10.1146/annurev.neuro.22.1.175
  32. Exp Neurol. v.168 no.2 Ischemia-induced degeneration of CA1 pyramidal cells decreases seizure severity in a subgroup of epileptic gerbils and affects parvalbumin immunoreactivity of CA1 interneurons Winkler DT;Scotti AL;Nitsch C https://doi.org/10.1006/exnr.2000.7605
  33. Neuron. v.28 no.2 Autoimmunityto munc-18 in Rasmussen's encephalitis Yang R;Puranam RS;Butler LS;Qian WH;He XP;Moyer MB;Blackburn K;Andrews PI;McNamara JO https://doi.org/10.1016/S0896-6273(00)00118-5
  34. J Neurosci. v.17 no.24 Sublethal oxygen-glucose deprivation alters hippocampal neuronal AMPA receptor expression and vulnerability to kainate-induced death Ying HS;Weishaupt JH;Grabb M;Canzoniero LM;Sensi SL;Sheline CT;Monyer H;Choi DW https://doi.org/10.1523/JNEUROSCI.17-24-09536.1997
  35. Dev Neurosci. v.20 no.4;5 Excitotoxicity and oxidative stress during inhibition of energy metabolism Zeevalk GD;Bernard LP;Sinha C;Ehrhart J;Nicklas WJ https://doi.org/10.1159/000017342