Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Immunomodulatory Effect of Methanol Extracts of Korean Oldenlandiae Herba and Radix

국내산 백화사설초 전초 및 뿌리 메타놀층의 면역조절 효과

  • Lee Eun Ok (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Rhee Yun Hee (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University) ;
  • Baek Nam In (School of Biotechnology and Plant Metabolism Research Center, Kyunghee University) ;
  • Ahn Kyoo Seok (College of Oriental Medicine, Kyunghee University) ;
  • Kim Sung Hoon (Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University)
  • 이은옥 (경희대학교 동서의학대학원 종양학 실험실) ;
  • 이연희 (경희대학교 동서의학대학원 종양학 실험실) ;
  • 백남인 (경희대학교 생명공학연구원) ;
  • 안규석 (경희대학교 한의과대학) ;
  • 김성훈 (경희대학교 동서의학대학원 종양학 실험실)
  • Published : 2004.04.01
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Abstract

For the evaluation of immunomodulatory effect of Korean Oldenlandiae Herb (OH) and Radix (OR), our experiment was performed with methanol extracts of Korean Oldenlandiae Herba and Radix. After administration of methanol extracts of Korean OH and OR for 7 days, Balb/C mice were immunized with sheep red blood cells. Four days later, splenic leukocytes were isolated and immunological experiments were performed. Rosette forming cells and plaque forming cells were significantly increased in Korean OH and OR treated mice compared with PBS treated control. Korean OH and OR also enhanced T and B lymphocytes, macrophage and natural killer cells by flowcytometric analysis. LPS-induced TNF-α and IL-6 levels were increased by OH and OR compared with untreated control. These results suggest that Korean OH and OR have immunomodulatory activity through regulation of cell-mediated immune and humoral immune response.

Keywords

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