Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Panax Ginseng Rg1 Enhances CD4+ T Cell Activities and Modulates Th1/Th2 Differentiation

인삼 Saponin Rg1이 분화된 보조 T cell의 cytokine 분비에 미치는 영향

  • Kwon Hong Rho (Department of Physiology, College of Oriental Medicine, KyungHee University) ;
  • Ko Eun Jung (Department of Physiology, College of Oriental Medicine, KyungHee University) ;
  • Bae Hyun Su (Department of Physiology, College of Oriental Medicine, KyungHee University, Purimed R&D Institute) ;
  • Hong Moo Chang (Department of Physiology, College of Oriental Medicine, KyungHee University) ;
  • Jung Seung Gi (Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Shin Min Kyu (Department of Physiology, College of Oriental Medicine, KyungHee University)
  • 권홍로 (경희대학교 한의과대학 생리학교실) ;
  • 고은정 (경희대학교 한의과대학 생리학교실) ;
  • 배현수 (경희대학교 한의과대학 생리학교실, 퓨리메드㈜ 기업부설연구소) ;
  • 홍무창 (경희대학교 한의과대학 생리학교실) ;
  • 정승기 (경희대학교 한의과대학 폐계내과학교실) ;
  • 신민규 (경희대학교 한의과대학 생리학교실)
  • Published : 2004.08.01
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Abstract

Panax ginseng has been used as a typical tonic medicine in Asian countries, such as Korea, China, and Japan. It has been reported that ginsenoside Rg1 in Panax ginseng increases the proportion of T helper cells in the whole T cells and promotes IL-2 gene expression in murine splenocytes. These studies imply that ginsenoside Rg1 increases the immune activity of CD4+ T cell, however the exact mechanism of ginsenoside Rg1 on helper T cell remains to be verified. The present study tried to elucidate the direct effect of Rg1 on helper T cell s activities and its Th1/Th2 lineage development. The results demonstrated that ginsenoside Rg1 had not mitogenic effects on the unstimulated CD4+ T cell, but augmented CD4+ T cell proliferation upon activating with anti-CD3/anti-CD28 antibodies in a dose dependent manner. Rg1 also enhanced the expression of cell surface protein CD69 on CD4+ T cell. In Th0 condition, ginsenoside Rg1 increases the expression of IL-2 mRNA, and enhances the expression of IL-4 mRNA on CD4+ T cells, suggesting Rg1 prefer to induce Th2 lineage development. In addition, ginsenoside Rg1 increases IL-4 secreting CD4+ T cell under Th2 skewed condition, while decreases IFN-γ secreting cell in Th1 polarizing condition. Thus, Rg1 enhances Th2 lineage development from naive CD4+ T cell both by increasing Th2 specific cytokine secretion and by repressing Th1 specific cytokine production. Therefore, these results suggest that ginsenoside Rg1 might be desirable agent for enhancing CD4+ T cell's activity, as well as the correction of Th1 dominant pathological disorders.

Keywords

References

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