동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제18권5호
  • /
  • Pages.1337-1342
  • /
  • 2004
  • /
  • 1738-7698(pISSN)
  • /
  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
권호 표지

오가피의 면역조절작용

Immunoregulatory Action of OGAPI

  • 김남석 (우석대학교 의약생명공학과) ;
  • 권진 (군장대학 의무행정과) ;
  • 고하영 (우석대학교 식품영양학과) ;
  • 최동성 (우석대학교 의약생명공학과) ;
  • 오찬호 (우석대학교 의약생명공학과)
  • Kim Nam Seok (Department of Medicinal Biotechnology, Woosuk University) ;
  • Kwon Jin (Department of Medical Administration, Kunjang College) ;
  • Koh Ha Young (Department of Food Nutrition, Woosuk University) ;
  • Choi Dong Seong (Department of Medicinal Biotechnology, Woosuk University) ;
  • Oh Chan Ho (Department of Medicinal Biotechnology, Woosuk University)
  • 발행 : 2004.10.01
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초록

The purpose of this research was to investigate the immunoregulatory effect and the leukemia cell apoptosis of EtOH extract of OGAPI(OGP). The proliferation of cultured splenocytes, thymocytes and mesenteric lymph node cells were enhanced by the addition of OGP. Splenic and thymic T lymphocytes, especially TH and Tc cells were significantly increased in OGP-administered mice. OGP markedly increased the production of γ-interferon in mice serum and accelerated the phagocytic activity in peritoneal macrophages. OGP treatment enhanced the apoptosis of L1210 mouse leukemia and Jurkat, Molt4 human leukemia cells, and increased the expression of apoptosis-related ICE, c-myc, p53 gene in Jurkat cell. These results suggest that OGP have an immunoregulatory action and anti-cancer activity.

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