Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects on Inhibition of Angiogenesis in MCF-7 Cells by the Aqueous Root Extract of Ailanthus Altissima

저근백피 추출물이 유선암 세포에서의 신생혈관 미치는 영향

  • Jeong Ji Hak (Department of Biology, College of Natural Sciences, Kyungpook National University) ;
  • Yun Young Gab (Department of Oriental medicine in Wonkwang University) ;
  • Jeon Byung Hun (Department of Oriental medicine in Wonkwang University) ;
  • Park Hae Ryoun (Department of Oral Pathology, College of Dentistry, Pusan National University) ;
  • An Won Gun (Department of Biology, College of Natural Sciences, Kyungpook National University)
  • 정지학 (경북대학교 자연과학대학 생물학과) ;
  • 윤용갑 (원광대학교 한의과대학) ;
  • 전병훈 (원광대학교 한의과대학) ;
  • 박혜련 (부산대학교 치과대학 구강병리학교실) ;
  • 안원근 (경북대학교 자연과학대학 생물학과)
  • Published : 2004.12.01
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Abstract

The cellular response to hypoxia is controlled to a large degree by the transcription factor Hypoxia-inducible factor-1(HIF-1). HIF-1 is a transcription factor that is activated by hypoxia and plays a critical role in the development of the cancer phenotype. HIF-1 regulates transcription of a number of genes crucial for tumor survival under hypoxic conditions, including vascular endothelial growth factor(VEGF), erythropoietin(Epo) and several glycolytic enzymes. Tumors in which hypoxia can not induce HIF-1 transcriptional activity remain small and fail to metastasize. In this study, we examined whether aqueous root extract of Ailanthus altissima (REA) downregulate HIF-1, VEGF and p53, and raise the possibility that depletion of these proteins and the anti proliferative activities of REA have any effects on inhibition of angiogenesis in MCF-7 cells. Pharmacologic targeting of specific signal transduction pathways related to oncogenic transformation is a promising approach in cancer treatment. Therefore, REA could be a candidate drug for further clinical development.

Keywords

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