The Prevalence of Macrolide Antibiotics Resistance in the Clinical Isolates of Common Respiratory Pathogens

임상분리 호흡기 감염증 원인 균주에서의 Macrolide계 항생물질의 내성

  • Yoon Eun-Jeong (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Ha Jang-Bum (Department of Life Science, University of Seoul) ;
  • Choi Eung-Chil (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
  • Shim Mi-Ja (Department of Life Science, University of Seoul)
  • 윤은정 (서울대학교 약학대학. 종합 약학 연구소) ;
  • 하장범 (서울시립대학교 생명과학과) ;
  • 최응칠 (서울대학교 약학대학. 종합 약학 연구소) ;
  • 심미자 (서울시립대학교 생명과학과)
  • Published : 2004.01.01

Abstract

The prevalence of resistance to a range of macrolides was determined for clinical isolates of common respiratory pathogens using NCCLS testing methods and interpretative criter ia.71.4% of Streptococcus pneumoniae, 62.3% of Staphylococcus aureus, 50.8% of coagulase-negative staphylococci and 4.4% of Strpetococcus pyogenes were erythromycin resistant. Also, the rates of resistance to other macrolides and clindamycin in these clinical isolates were as high as to eryth -romycin. Almost all of the macrolide-resistant isolates were positive for erm of the methylase gene, or mef of the efflux gene.

Keywords

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