한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제32권3호
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  • Pages.271-276
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  • 2004
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  • 1598-642X(pISSN)
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  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

영지버섯 균사체(Ganoderma lucidum IY009)로부터 추출한 $\beta$-Immunan의 시스플라틴 유발 신독성 보호효과

Protective Effects of $\beta$-Immunan Isolated from the Mycelium of Ganoderma lucidum IY009 against Cisplatin-induced Nephrotoxicity

  • 발행 : 2004.09.01
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초록

$\beta$-Immunan was proteoglycan obtained from mycelium of Ganoderma lucidum IY009. In this study, the protective effects of $\beta$-Immunan, against the CDDP induced in vitro cytotoxicity and in vivo renal toxicity, was measured. Concentration dependent cytotoxicities of CDDP in normal kidney cells (Vero, TCMK-l) were reduced by $\beta$-Immunan treatment. Increased renal toxicity factors, such as elevation of blood urea nitrogen (BUN) and serum creatinine, reduction of kidney weight and malonidialdehyde (MDA), by intraperitoneal administration of CDDP in rats was improved. These results indicated that $\beta$-Immunan have a protective effects against the CDDP induced renal toxicity, however, it needed to confirm the detailed mechanism for therapeutic effects.

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