Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Inhibition of Epstein-Barr Virus by the Triterpenoid Betulin Diphosphate and Uvaol

  • Muhammad, Amjad (Clinical Laboratory Science Program, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University) ;
  • Carlson, Robert M. (Department of Chemistry, University of Minnesota) ;
  • Krasutsky, Pavel (Department of Chemistry, University of Minnesota) ;
  • Karim, M.Reza-Ul (Department of Biology, College of Science and Engineering, 10 University Drive, University of Minnesota)
  • Published : 2004.10.01
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Abstract

Betulin, a pentacyclic triterpenoid isolated from the bark of Betula papyrifera. Laboratory synthesized structural analogs were tested for antiviral activities against Epstein-Barr Virus (EBV) by immunofluorescent antiviral assay. Among the several analogs tested, betulin 3,28-diphosphate and uvaol exhibited significant antiviral activities against EBV. The $EC_{50}$ of betulin 3,28-diphosphate and uvaol was found to be $0.6\mu{M}$ and $0.7\mu{M}$ respectively.

Keywords

References

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