Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Administration of Agonistic Anti-4-1BB Monoclonal Antibody Inhibits Melanoma Metastasis Via IFN-${\gamma}$ Production

  • Ju, Seong-A (Immunomodulation Research Center, University of Ulsan) ;
  • Lee, Sang-Chul (Immunomodulation Research Center, University of Ulsan) ;
  • Seok, Moon-Hong (Institute of Basic Sciences, Kyungpook National University) ;
  • Kim, Byung-Sam (Immunomodulation Research Center, University of Ulsan)
  • Published : 2004.06.01
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Abstract

The purpose of this study was to analyze inhibitory effects of anti-4-1BB monoclonal antibody on melanoma metastasis The 4-1BB (CD137) T cell molecule is a member of the TNF receptor family and its activation by either 4-1BB ligand or antibody induces T cell activation and growth. In the present study, administration of anti-4-1BB mAb induced inhibition of melanoma metastasis. Agonistic anti-4-1BB mAb induced not only CD$8^+$4-1BBT cells but also CD$8^+$IFN-${\gamma}$$^{+}$ T cell population. In the presence of anti-CD3 antibody, lymphocytes produced high levels of IFN-${\gamma}$ and low levels of IL-4 in anti-4-1BB mAb treated group. Exposure of melanoma cells to IFN-${\gamma}$ induced expression of MHC-I molecules. Thus, the increase in number of CD$8^+$T cells and enhanced MHC-I expression on B16F10 cells by augmented IFN-${\gamma}$ production in response to anti-4-1BB mAb may result in suppression of tumor growth and metastasis.s.

Keywords

References

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