Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
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Tra2${\alpha}$ and hnRNP K might be Functional Partners of Rbm for Regulation of RNA Processes during Spermatogenesis

  • Lee, Jungmin (School of Biological Sciences, Seoul National University) ;
  • Kim, Euisu (School of Biological Sciences, Seoul National University) ;
  • Jang, Sung Key (Department of Life Science, Pohang University of Science and Technology) ;
  • Rhee, Kunsoo (School of Biological Sciences, Seoul National University)
  • Published : 2004.03.01
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Abstract

Rbm is a male infertility gene located in the AZFb region of the Y chromosome. Expression pattern of Rbm indicates that Rbm is critical for early phase of male germ cell development. It shares strong structural homology with hnRNP G, suggesting a function as an RNA processing factor. In order to gain a clue on the molecular mechanisms of Rbm on male germ cell development, we examined interactions of Rbm with selected proteins in yeast. The results revealed specific interactions between Rbm, hnRNP K and Tra2${\alpha}$. These results suggest that hnRNP K and Tra2${\alpha}$ may be functional partners of Rbm in male germ cells. We propose a model in which hnRNP K may playa role as a platform for Rbm and Tra2${\alpha}$.

Keywords

References

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