Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Improvement of Haemostasis Mediated by Anti-Platelet Activities by Plant Vinegar

목초액의 혈소판 응집억제를 통한 혈행개선 작용에 관한 연구

  • 김영대 (서울대학교 약학대학 종합약학연구소) ;
  • 배옥남 (서울대학교 약학대학 종합약학연구소) ;
  • 정승민 (서울대학교 약학대학 종합약학연구소) ;
  • 정진호 (서울대학교 약학대학 종합약학연구소)
  • Published : 2004.06.01
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Abstract

We investigated the effects of plant vinegar on platelets and blood coagulation system. Plant vinegar inhibited in vitro platelet aggregation in a concentration dependent manner, when platelets were activated by thrombin and collagen. In addition, plant vinegar showed inhibitory effects on the serotonin secretion induced by thrombin in a concentration dependent manner. However, treatment with plant vinegar to platelets did not induce any cytotoxicity, as determined by the release of lactate dehydrogenase. Plant vinegar did not change the coagulation parameters such as activated partial thromboplastin time (aPTT) and prothrombin time (PT) using rat citrated plasma. In vivo study revealed that, treatment with plant vinegar prolonged the bleeding time from mouse tail. All these results suggest that plant vinegar might improve blood hemostasis mediated via anti platelet activities.

Keywords

References

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