Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Changes of Pulmonary Function!) During 60 days of Welding Fume Exposure Period 1m Sprague-Dawley Rats

Sprague-Dawley 랫드에서 60일간 용접흄 폭로에 의한 폐기능 변화

  • 성재혁 (산업안전보건연구원, 산업화학물질연구센터) ;
  • 최병길 (연세대학교 원주캠퍼스 환경공학과) ;
  • 맹승희 (산업안전보건연구원, 산업화학물질연구센터) ;
  • 김수진 (산업안전보건연구원, 산업화학물질연구센터) ;
  • 정용현 (산업안전보건연구원, 산업화학물질연구센터) ;
  • 한정희 (산업안전보건연구원, 산업화학물질연구센터) ;
  • 현진숙 (산업안전보건연구원, 산업화학물질연구센터) ;
  • 송경석 (서울대학교 수의과대학) ;
  • 조영봉 (연세대학교 원주캠퍼스 환경공학과)
  • Published : 2004.03.01
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Abstract

Respiratory effects in full time welders include bronchitis, airway irritation, lung function changes, and lung fibrosis. Welder's pneumoconiosis has been generally determined to be benign and not associated with respiratory symptoms based on the absence of pulmonary function abnormalities in welders with marked radiographic abnormalities. Accordingly, to investigate pulmonary function changes during 60 days induced by welding-fume exposure, male Sprague-Dawley rats were exposed to manual metal arc-stainless steel (MMA-SS) welding fumes with concentrations of 64.8$\pm$0.9 mg/$m^3$ (low dose) and 107.8 $\pm$ 2.6 mg/$m^3$ (high dose) total suspended particulates for 2 hr/day, 5 days/week in an inhalation chamber for 60 days. Pulmonary function was measured every week with whole body plethysmograph compensated (WBP Comp, SFT38116, Buxco Electronics, Sharon, CT). The rats exposed to the high dose of welding fumes exhibited statistically significant (p<0.05~0.01) body weight decrease as compared to the control whereas cell number increase of the bronchoalveolar lavage fluid (BALF) (total cell, macrophage, polymorphonuclear cell and lymphocyte) during the 60 days exposure period. And only tidal volume was significantly decreased in dosedependantly during 60 days of MMA-SS welding fume exposure. This pulmonary function change with inflammatory cell recruitment confirms the lung injury caused by the MMA-SS welding fume exposure.

Keywords

References

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