Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Triterpenoids from Acanthopanax koreanum Root and Their Inhibitory Activities on NFAT Transcription

  • Cai, Xing-Fu (College of Pharmacy, Chungnam National University) ;
  • Lee, Im-Seon (College of Pharmacy, Chungnam National University) ;
  • Shen, Guanghai (College of Pharmacy, Chungnam National University) ;
  • Dat, Nguyen-Tien (College of Pharmacy, Chungnam National University) ;
  • Lee, Jung-Joon (College of Pharmacy, Chungnam National University) ;
  • Kim, Young-Ho (College of Pharmacy, Chungnam National University)
  • Published : 2004.08.01
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Abstract

Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-［(${\alpha}-L-rhamnopyranosyl(1{\rightarrow}4)-{\beta}-D-glucopyrano-syl(1{\rightarrow}6)]-{\beta}-D-glucopyranosyl]$ ester (3), and ursolic acid (4) by physicochemical and spectro-scopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor ($IC_{50}:{\;}12.65{\;}{\mu\textrm{m}}$).

Keywords

References

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