Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antiinflammatory Activity of Hyperin from Acanthopanax chiisanensis Roots

  • Lee, Sang-Hyun (College of Pharmacy, Seoul National University, Natural Products Research Institute, Seoul National University) ;
  • Jung, Sang-Hoon (Natural Products Research Institute, Seoul National University, Natural Products Research Center, Korea Institute of Science and Tech-nology) ;
  • Lee, Yeon-Sil (Natural Products Research Institute, Seoul National University, Seokwon Life Science Research Institute, World Sea Green Co. Ltd.) ;
  • Yamada, Masateru (Graduate School of Pharmaceutical Sciences, Tohoku University) ;
  • Kim, Bak-Kwang (College of Pharmacy, Seoul National University) ;
  • Ohuchi, Kazuo (Graduate School of Pharmaceutical Sciences, Tohoku University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, Seoul National University, Seokwon Life Science Research Institute, World Sea Green Co. Ltd.)
  • Published : 2004.06.01
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Abstract

The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E$_2$ (PGE$_2$）production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate （TPA）. Hyperin was isolated as an active principle from the ethyl acetate fraction. It sup-pressed not only $PGE_2$ production but also nitric oxide （NO） production in vitro in a concentration dependent manner. their $IC_{50}$, being 24.3 and $32.9{\;}{\mu}M$, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo.

Keywords

References

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