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The Pharmaceutical Society of Korea (대한약학회)
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Some Pyridazinone and Phthalazinone Derrivatives and Their Vasodilator Activities

  • Seref Demirayak (Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu) ;
  • Ismai Kayagil (Dept. of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Anadolu) ;
  • Kevser Erol (Dept. of Pharmacology, Faculty of Medicine, University of Osmangazi) ;
  • Basar Sirmagul (Dept. of Pharmacology, Faculty of Medicine, University of Osmangazi) ;
  • Ahmet Cagri Karaburun (Dept. of Pharmacology, Faculty of Medicine, University of Osmangazi)
  • Published : 2004.01.01
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Abstract

In this study, 6-[( 4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5-dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4-aminophenyl)-1(2H)-phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.

Keywords

References

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