Archives of Pharmacal Research

  • 제27권7호
  • /
  • Pages.730-733
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  • 2004
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Triterpenoid Saponin from Viola hondoensis W.Becker et H Boss. and Their Effect on MMP-1 and Type I Procollagen Expression

  • Moon, Hyung-In (Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipital) ;
  • Chung, Jin-Ho (Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipita) ;
  • Lee, Joong-Ku (Korea Research Institute of Bioscience and Biotechnolog) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
  • 발행 : 2004.07.01
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초록

Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-${\beta}$-D-glucopyrano$yl-(1${\to}$2)-O-${\beta}$-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.

키워드

참고문헌

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