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Triterpenoid Saponin from Viola hondoensis W.Becker et H Boss. and Their Effect on MMP-1 and Type I Procollagen Expression  

Moon, Hyung-In (Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipital)
Chung, Jin-Ho (Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hosipita)
Lee, Joong-Ku (Korea Research Institute of Bioscience and Biotechnolog)
Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
Publication Information
Archives of Pharmacal Research / v.27, no.7, 2004 , pp. 730-733 More about this Journal
Abstract
Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-${\beta}$-D-glucopyrano$yl-(1${\to}$2)-O-${\beta}$-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.
Keywords
Viola hondoensis; Violaceae; Triterpenoid saponin; MMP1 inhibitor;
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Times Cited By Web Of Science : 11  (Related Records In Web of Science)
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