Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

The Influences of Meles meles Oil on Health Status, Diabetic Index and Serum Lipid Profile in Non - Insulin Dependent Diabetes Mellitus Patients

오소리 지질이 인슐린 비의존형 당뇨환자의 건강상태 당뇨지표 및 혈청지질농도에 미치는 영향

  • 박성혜 (원광대학교 한의학전문대학교 한약자원개발학과) ;
  • 백승화 (충북도립대학 식품생명과학) ;
  • 한종현 (원광대학교 한의학전문대학교 한약자원개발학과)
  • Published : 2004.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the possibility of Meles meles oil as an functional resource. To assess the effects of Meles meles oil in 25 non-insulin dependent diabetes mellitus (DM) persons, we examined changes of fat intake level, hematological and chemical variables, serum DM indices and lipid contents during the Meles meles oil supplementation. Polyunsaturated fatty acid and $\omega$3 fatty acid intake were significantly increased by Meles meles oil intakes. The levels of LDL-cholesterol and triglyceride were significantly decreased while HDL-cholesterol was significantly increased. Iron status improved during Meles meles oil intakes. These results show that modest dose of Meles meles oil supplementation can decrease serum triglyceride, cholesterol level without any changes in blood glucose level in NIDDM patients. These results indicated that Meles meles oil diet is effective therapeutic regimen for the control of metabolic derangements in diabetes mellitus. Also, these results imply that Meles meles oil can be used as possible food resources and functional food materials. However, large amounts of Meles meles oil should be used cautiously in NIDDM patients.

본 연구자들은 다른 동물성 지질에 비해 콜레스테롤 함량이 낮고 불포화지방산 함량이 높은 오소리 지질을 당뇨환자들에게 섭취시킨 후 혈당, 혈청의 당뇨지표 및 혈청 지질의 변화를 관찰하여 당뇨환자들에게 동물성인 오소리 지질 섭취가 혈당유지 및 합병증 관리 에 합당한가를 평가하여 오소리 지질을 기능성 식품의 원료로 활용할 수 있는가를 확인하고자 하였다. 일일 평균 7.26 g의 오소리 지질을 12주간 섭취한 후에 총 지질의 섭취량은 유의적 인 차이가 없었으나 $\omega$3계 지방산과 다가불포화지방산의 섭취량은 유의적으로 증가하였고 콜레스테롤의 섭취량은 유의적으로 감소된 결과를 나타냈다. 공복 시 혈당이 오소리 지질의 섭취에 따라 유의적인 상승을 나타내지 않았고 fructosamine과 glucagon농도는 오소리 지질의 섭취 6주째부터 유의적으로 상승되었다. 혈청의 LDL-콜레스테롤 및 중성지방의 농도는 오소리 지질 섭취에 따라 유의적으로 감소되었고 HDL-콜레스테롤 농도는 유의적으로 상승되었다. 또한 일반적인 건강상태 판정지표로 살펴볼 때 간기능 및 철분 영양상태가 증진되었다. 위의 결과들로 보아 제2형 당뇨환자의 12주간 오소리 지질의 섭취는 건강상태와 혈청지질 profile에는 유익한 영향을 주었고 따라서 동물성인 오소리 지질을 건강보조식품으로 사용하거나 기능성 식품의 원재료로 활용이 가능할 것으로 판단된다. 앞으로 오소리 지질 섭취 수준을 달리한 dose-response 실험을 통해 섭취 수준과 혈청지질 및 지방산 조성의 변화를 관찰하여 오소리 지질의 광범위한 활용을 위한 체계적인 자료를 더 확보하고자 한다.

Keywords

References

  1. 이희훈, 한석록. 2002. 약용 오소리 사육전서. 특수출판, 서울. p 14-21.
  2. Park SH, Park SJ, Kim KY, Han JH. 2004. Study on theMeles meles as applications in edible food resource. KoreanJ Food Cookery Sci 20: 57-62.
  3. 식품의약품안전청. 2003. 식품의약품안전청 고시 제 2003-33호.
  4. 중앙대사전 편찬위원회. 2002. 중약대사전. 정담출판사, 서울.p 1101.
  5. 허준. 2002. 동의보감. 근영출판사, 서울. p 462.
  6. 황도연. 1978. 방약합편. 남산당, 서울. p 128.
  7. 김현제, 홍윤식. 1992. 한의학사전. 의성당, 서울. p 37-39.
  8. 한국식품공업협회. 2002. 식품공전. 문영사, 서울. p 541-581.
  9. Spiller GA. 1996. Lipids in human nutrition. 2nd ed. CRC Press, New York. p 313-317.
  10. Singer P, Jaeger W, Viogt S. 1984. Defective desturation andelongation of n-6 and n-3 fatty acid in hypertensivepatients. Prostaglandins Leukotrienes Med 15: 159-167. https://doi.org/10.1016/0262-1746(84)90173-2
  11. Weber PC, Leaf A. 1991. Cardiovascular effects of ${\omega}3$ fatty acid. World Rev Nutr Diet 66: 218-225.
  12. Seed M, Hoppichler F, Reaveley D. 1990. Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia. N Engl J Med 322: 1494-1499. https://doi.org/10.1056/NEJM199005243222104
  13. Wikund O, Angelin B, Olofsson SO. 1990. Apolipoprotein(a) and ischaemic heart disease in familial hypercholesterolaemia.Lancet 35: 1360-1367.
  14. Cambell RK, Steil CF. 1998. Diabetes clinical pharmacy andtherapeutics. William & Wilks, Washington DC. p 48-61.
  15. Abrams JJ, Ginberg H, Grundy SM. 1982. Metabolism ofcholesterol and plasma triglycerides in non-ketotic diabetesmellitus. Diabetes 31: 903-910. https://doi.org/10.2337/diabetes.31.10.903
  16. Urano S, Midori HH, Tochihi N, Matsuo M, Ito H. 1991.Vitamin E and susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics.Lipid 26: 56-61.
  17. Bailey CJ, Day C. 1989. Traditional plant medicines astreatments for diabetes. Diabetes Care 12: 553-564. https://doi.org/10.2337/diacare.12.8.553
  18. Choi JS, Chung HY, Young HS. 1990. A preliminary studyon hypocholesterolemic and hypoglycemic activities of somemedicinal plants. Korean J Pharmacogn 21: 153-157.
  19. Kim OK, Lee EB. 1992. The screening of plants for hypoglycemicaction in normal and alloxan-induced hyperglycemicrats. Korean J Pharmacogn 23: 117-119.
  20. Yoon KB, Jang JK. 1989. Wild vegetables good for health. Seokoh Pub, Seoul. p 334.
  21. The Korean Nutrition Society. 2001. Can-Pro.
  22. Research Center for Functional Food. 2001. Program DI49.Wonkwang Univerisity.
  23. 이세열, 정윤섭. 1993. 임상병리검사법. 연세대학교 출판부,서울. p 51-67.
  24. Choi MJ. 1993. Relation of body fat distribution to calories intake, blood glucose and exercise in female diabetics.Korean J Nutr 26: 164-171.
  25. Horwath CC, Worlsey A. 1991. Dietary habits of elderlypersons with diabetes. J Am Diet Assoc 91: 553-558.
  26. Karlstrom B, Nydahl M, Vessby B. 1989. Dietary habits andeffects of dietary advice in patients with type II diabetes.Euro J Clin Nutr 43: 59-63.
  27. Lee KY, Jang MR, Kim EK, Huh KB. 1991. A study on bodyfat distribution in obese human. Korean J Nutr 24: 157-165.
  28. 보건복지부. 1990. 국민영양조사보고서.
  29. Choi WK. 1998. Serum glucose and lipie profiles according to dietary carbohydrate and lipid intake ratio in NIDDM patients. Korean J Home Economic Association 36: 183-191.
  30. Song MH, Lee JM. 1993. A study on food and nutrientsintake and blood constituents of diabetics by obese index.Korean J Nutr 26: 953-966.
  31. Lundgren H, Bengtsson C, Blohme G, Isaksson B, LapidusL, Lenner RA, Saek A, Winther E. 1989. Dietary habits and incidence of non-insulin-dependent diabetes mellitus in a population study of women in Gothenberg, Sweden. Am JClin Nutr 49: 708-716. https://doi.org/10.1093/ajcn/49.4.708
  32. Rho SN, Ko HS. 1997. A clinical properties on nutrients intake and serum concentration of diabetes subjects by duration in Ansung, Kyunggi-do. Korean J Nutr 30: 1203-1210.
  33. Moon SJ, Hong SM. 1994. A study on psychological symptomsand nutritional status of diabetic patients. Korean JNutr 27: 172-180.
  34. Lee JS, Lee MH, Chang YK, Ju JS, Son HS. 1995. Effect of buckwheat diet on serum glucose and lipid metabolism in NIDDM. Korean J Nutr 28: 809-817.
  35. Baker JR, Metalf PA, Holdaway IM, Johnson RN. 1985.Serum fructosamine concentration as measure of bloodlucose control type I diabetes mellitus. Br Med J 290: 352-356. https://doi.org/10.1136/bmj.290.6465.352
  36. Lloyd D, Marples J. 1984. Simple colorimetry of glycatedserum protein in a contrifugal analyzer. Clin Chem 30:1688-1702.
  37. Park HR. 1987. Frequency of chronic diabetic complication,indices of glucose control and serum fructosamine in noninsulindependent diabetics. Diabetes 12: 45-50.
  38. Wee SO, Kim DM, Sung SK, Yoo HJ. 1986. Serum c-peptideconcentration as an index of insulin treatment in NIDDMpatients. Diabetes 11: 57-61.
  39. Vega GL. 1992. Lipid metabolism. Water de Gruyter, Germany.p 59-70.
  40. Deck C. 1989. Effects of modest doses of omega-3 fatty acidson lipids and lipoproteins in hypertriglyceridemic subjects.Arch Intern Med 149: 1857-1862. https://doi.org/10.1001/archinte.149.8.1857
  41. Childs MT, King IB, Knopp PH. 1990. Divergent lipoproteinresponses to fish oil with various ratios of eicosapentaenoicacid and docosahexaenoic anid. Am J Clin Nutr 52: 632-639. https://doi.org/10.1093/ajcn/52.4.632
  42. Popp-Snijders C, Bilo HJG, Heine RJ. 1990. Fish oil andglycemic control. Diabetes Care 13: 80-81. https://doi.org/10.2337/diacare.13.1.80
  43. Paik IK, Yoon JY, Chung YS, Chang HJ, Lee JH, Lee EJ, Lee HC, Huh KB. 1993. The influences of different doses of fish oil on serum lipids in patients with NIDDM. Korean J Nutr 26: 672-679.
  44. Nalasanos TH, Stacpoole PW. 1991. Biological effects of $\omega$-3 fatty acids in diabetes mellitus. Diabetes Care 14: 1160-1179. https://doi.org/10.2337/diacare.14.12.1160
  45. Drevon CA. 1992. Marine oils and their effects. Nutr Rev50: 38-45. https://doi.org/10.1111/j.1753-4887.1992.tb01288.x
  46. Harris WS, Zucher M, Dujovne C. 1988. $\omega$-3 fatty acids in hypertriglyceridemic patients. Am J Clin Nutr 48: 992-997. https://doi.org/10.1093/ajcn/48.4.992