Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Cytotoxic Activity of 1-(1-Benzoylindoline-5-sulfonyl)-4-phenylimidazolidinones

  • Sang-Hun Jung (College of Pharmacy, Chungnam National University) ;
  • Hui-Soon Lee (College of Pharmacy, Chungnam National University) ;
  • Nam-Soo Kim (College of Pharmacy, Chungnam National University) ;
  • Hwan-Mook Kim (Korea Research Institute of Bioscience and Biotechnolog) ;
  • Moonsun Lee (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt) ;
  • Dong-Rack Choi (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt) ;
  • Jung-Ah Lee (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt) ;
  • Yong-Ho Chung (Research Laboratories, Dong-Wha Pharm, Ind. Co. Lt) ;
  • Eun-Yi Moon (Research Laboratories, Dong-Wha Pharm, Ind. Co. Ltd)
  • Published : 2004.05.01
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Abstract

The novel 1-(1-benzoylindoline-5-sulfonyl)-4-phenyl-4,5-dihydroimidazolones 2 shows highly potent and broad cytotoxicities. Their cytotoxicities against human lung carcinoma A549, human chronic myelogenous leukemia K562, and human ovarian adenocarcinoma SK-OV-3 are compatible with doxorubicin. Compound 2p (1-[(4-aminobenzoyl)indoline-5-sulfonyl])-4-phenyl-4,5-dihydroimidazolone) exhibits a cytotoxicity that is far more potent than doxorubicin and also exhibits highly effective antitumour activities against murine (3LL, Colon 26) and human xenograft (NCI-H23, SW620) tumor models.

Keywords

References

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