Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Optimal Fermentation Conditions for Enhanced Glutathione Production by Saccharomyces cerevisiae FF-8

  • Cha, Jae-Young (Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University) ;
  • Park, Jin-Chul (Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University) ;
  • Jeon, Beong-Sam (BioHub Co., Ltd, Institute of Life Science (33)-617, Gyeongsang National University) ;
  • Lee, Young-Choon (Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University) ;
  • Cho, Young-Su (Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University)
  • Published : 2004.03.01
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Abstract

The influence of feedstock amino acids, salt, carbon and nitrogen sources on glutathione production by Saccharomyces cerevisiae FF -8 was investigated. Glucose, yeast extract, KH$_2$PO$_4$, and L-cysteine were found to be suitable feedstock. Highest glutathione production was obtained after cultivation with shaking for 72 h in a medium containing glucose 3.0% (w/v), yeast extract 3.0%, KH$_2$PO$_4$ 0.06% and L-cysteine 0.06%. The glutathione concentration achieved using this medium increased 2.27-fold to 204 mg/l compared to YM basal medium.

Keywords

References

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