YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Studies on the Wound Healing by the PVA-soft hydrogel

화상 및 창상 치료용 외용제제 개발에 대한 기초 연구

  • Published : 2004.02.01
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Abstract

A PVA-soft hydrogel, which is a semi-solid form in container, whereas after applying on the skin, it formed a thin layer within a few minutes. In this study, we prepared a novel type PVA-soft hydrogel containing 6-methyluracil as active drug, and the therapeutic value was characterized. To evaluate the therapeutic value of the PVA-soft hydrogel containing drug, various animal models, thermal burn model, incision & excision wound rat model were used. We also measured the wound size and breaking strength to calculate the wound healing extent after single or multiple administration. The wound size of soft hydrogel treated group decreased rapidly than that of control group after multiple dosing in excision wound model. And, the breaking strength of the soft hydrogel treated group was greater than that of control group in incision wound model.

Keywords

References

  1. N. Engl. J. Med. v.311 no.7 Transderm Scop for prevention of motion sickness Johnson,P.;Hansen,D.;Matarazzo,D.;Petterson,L.;Swisher,C.;Trappolini,A. https://doi.org/10.1056/NEJM198408163110713
  2. Am. J. Cardiol. v.61 no.9 Transdermal nitroglycerin patches for silent myocardial ischemia during antianginal treatment Schneeweiss,A.;Marmor,A. https://doi.org/10.1016/0002-9149(88)90088-4
  3. Am. Heart, J. v.108 no.1 Pharmaceutical considerations of transdermal nitroglycerin delivery: the various approaches Chien,Y.W. https://doi.org/10.1016/0002-8703(84)90577-5
  4. Drug Intell. Clin. Pharm. v.18 no.1 Adverse dermatologic reaction to transdermal nitroglycerin Letendre,P.W.;Barr,C.;Wilkens,K. https://doi.org/10.1177/106002808401800113
  5. J. Kor. Pharm. Sci. v.29 no.2 Anti-inflammatory Activity of Ketoprofen Soft Hydrogel. Lee,E.K.;Shin,Y.H.;Lee,C.H.
  6. J. Pharm, Pharmacol. v.42 no.10 Design of a polyvinyl alcohol hydrogen containing phospholipid as controlled-release vehicle for rectal administration of (dl)-propranolol HCI Morimoto,K.;Fukanoki,S.;Hatakeyama,Y.;Nagayasu,A.;Morisaka,K. https://doi.org/10.1111/j.2042-7158.1990.tb06567.x
  7. Pharm. Res. v.6 no.4 Evaluation of polyvinyl alcohol hydrogel as a sustained-release vehicle for rectal administration of indomethacin Morimoto,K.;Nagayasu,A.;Fukanoki,S.;Morisaka,K.;Hyon,S.H.;Ikada,Y. https://doi.org/10.1023/A:1015958710435
  8. J. Biomed. Mater. Res. v.42 no.1 A new drug delivery system with controlled release of antibiotic only in the presence of infection Suzuki,Y.;Tanihara,M.;Nishimura,Y.;Suzuki,K.;Kakimaru,Y.;Shimizu,Y. https://doi.org/10.1002/(SICI)1097-4636(199810)42:1<112::AID-JBM14>3.0.CO;2-N
  9. Strahlentherapie v.153 no.12 Effects OR 6-methyl-uracil upon the phargocytic activity in mice following whole-body X-irradiation OR 2,4,6-triethyleneimino-s-triazine treatment Raake,W.;Temple,K.
  10. J. Pharm. Pharmacol. v.45 no.9 Further evaluation of a new penetration enhancer, HPE-101 Yano,T.;Higo,N.;Furukawa,K.:Tsuji,M.;Noda,K.;Otagiri,M. https://doi.org/10.1111/j.2042-7158.1993.tb05683.x
  11. J. Trauma v.20 no.12 The effect of Hydron burn wound dressing on burned rat and rabbit ear wound healing Dressler,D.P.;Barbee,W.K.;Sprenger,R. https://doi.org/10.1097/00005373-198012000-00003
  12. Am. J. Pathol. v.142 no.2 U75412E, a lazaroid, prevents progressive burn ischemia in a rat burn model Choi,M.;Ehrlich,H.P.
  13. Burns v.18 no.5 Wound healing of burns in rats treated with a new amino acid copolymer membrane Eloy,R.;Cornillac,A.M. https://doi.org/10.1016/0305-4179(92)90041-R
  14. J. Trauma v.32 no.5 Elucidating the vascular response to burns with a new rat model Regas,F.C.;Ehrlich,H.P. https://doi.org/10.1097/00005373-199205000-00004
  15. Burns v.23 no.5 Hypernatremia deepens the demarcating borderline of leukocytic infiltration in the burn wound Kuroda,T.;Harada,T.;Tsutsumi,H.;Kobayashi,M. https://doi.org/10.1016/S0305-4179(97)00016-8
  16. Wiad Lek v.50 no.1 Evaluation of the usefulness of dressings made from chitosan and lyophilized human placenta on wound healing Drenda,P.;Lampe,P.;G'orka,Z.;Bursig,H.;Dylag,S.
  17. Lasers Surg. Med. v.20 no.3 Helium-neon laser irradiation at fluences of 1, 2, and 4 J/㎠ failed to accelerate wound healing as assessed by boty wound contracture rate and tensile strength Allendorf,J.D.;Bessler,M.;Huang,J.;Kayton,M.L.;Laird,D.;Nowygrod,R.;Treat,M.R. https://doi.org/10.1002/(SICI)1096-9101(1997)20:3<340::AID-LSM13>3.0.CO;2-H
  18. Surgery v.124 no.2 Metalloproteinase inhibitors and wound healing: a novel enhancer of wound strength Witte,M.B.;Thornton,F.J.;Kiyama,T.;Efron,D.T.;Schulz,G.S.;Moldawer,L.L.;Barbul,A. https://doi.org/10.1016/S0039-6060(98)70154-0
  19. Biomed. Sci. Instrum. v.33 Influence of naproxen on the healing of open excision wound in rats Margaret,I.;Jamil,K.
  20. J. Ethnopharmacol. v.56 no.2 Wound healing activity of Leucas lavandulaefolia Rees Saha,K.;Mukherjee,P.K.;Das,J.;Pal,M.;Saha,B.P. https://doi.org/10.1016/S0378-8741(97)01522-5