YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Acute Oral Administration of Mancozeb on the Immune Function in Mice

Mancozeb의 급성노출이 마우스의 면역기능에 미치는 영향

  • 정애희 (서울특별시보건환경연구원) ;
  • 표명윤 (숙명여자대학교 약학대학)
  • Published : 2004.02.01
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Abstract

Mancozeb, a polymeric complex of zinc and manganese salts of ethylene bisthiocarbamate (EBDC), is used widely in agriculture as fungicides, insecticides, and herbicides. Mancozeb can be occupationally and environmentally exposed to human and has been reported to induce estrogenic activity, therein it is considered as an endocrine disrupter, We investigated the effects of acute exposure of Mancozeb on the immune function in mice. After single oral administration of Mancozeb to female ICR mice, the immunopathological parameters (body- and organ-weight, splenic cellularity hematological parameters), mitogen (Con A, PHA+IL-2, LPS)-induced splenocyte proliferation (SP) and splenic IgM plaque forming cell (PFC). WBC and splenic cellularity were decreased, but liver-, kidney-, and spleen-weight were increased when compared with control group. Splenic IgM PFC against SRBC was slightly lowered. Mitogen-induced proliferation of spleen cells from Mancozeb-treated mice was not signifcantly changed ex vivo, however, SP in vitro were significantly lowered in concentration dependent manner. These results indicate that Mancozeb could affect the immune function in mice.

Keywords

References

  1. 농약연보 농약공업협회
  2. Environmental Health Perspectives v.106 no.8 Mode of carcinogenic action of pesticides inducing thyroid follicular cell tumors in rodents Hurley,P.M.;Hill,R.N.;Whiting,R.J. https://doi.org/10.2307/3434175
  3. J. Appl. Toxicol. v.17 no.6 Studies on rat thyroid after oral administration of mancozeb : morphological and biochemical evaluations Kackar,R.;Srivastava,M.K.;Raizada,R.B. https://doi.org/10.1002/(SICI)1099-1263(199711/12)17:6<369::AID-JAT449>3.0.CO;2-Q
  4. Ind. J. Exp. Biol. v.31 Effect of oral administration of fungicide-mancozeb on thyroid gland of rat Trivedi,N.;Kakkar,R.;Srivastava,M.K.;Mithal,A.;Raizada,R.B.
  5. Bull. Environ Contam. Toxicol. v.44 Enhancement of tumor-initiation activity of DMBA by the carbamate fungicide Mancozeb Mehrotra,N.K.;Kumar,S.;Yogeshwer,S. https://doi.org/10.1007/BF01702359
  6. Meded. Rijksuniv. Gent. Fak. Landbouwkd. Toegep. Biol. Wet. v.66 no.2b One-generation reproduction toxicity study of mancozeb and lead acetate. Varnagy,L.;Budai,P.;Molnar,E.;Takacs,I.;Fejes,S.
  7. Fd. Chem. Toxic. v.27 no.8 Subacute toxicological examination of Dithane M-45 Szepvolgyi,J.;Nagy,K.;Sajgone;Vukan,K.;Regoly-Merei,A.;Soos,K.;Toth,K.;Pinter,A.;Antal,M. https://doi.org/10.1016/0278-6915(89)90049-5
  8. Rana pipiens, and Bufoamericanus. Bull. Environ. Contam. Toxicol. v.64 Species-and age-related differences in susceptibility to pesticide exposure for two Amphibians Harris,M.L.;Chora,L.;Bishop,C.A.;Bogart,J.P. https://doi.org/10.1007/s001289910039
  9. Reproductive Toxicology v.14 Effect of mancozeb on ovarian compensatory hypertrophy and biochemical constituents in hemicastrated albino rat Mahadevaswami,M.P.;Jadaramkunti,U.C.;Hiremath,M.B.;Kaliwal,B. https://doi.org/10.1016/S0890-6238(00)00064-2
  10. Ind. Health v.39 no.3 Induction of gonadal toxicity to female rats after chronic exposure to mancozeb Baligar,P.N.;Kaliwal,B.B. https://doi.org/10.2486/indhealth.39.235
  11. Ind. Health v.40 no.2 Anti-implantation effect of a carbamate fungicide mancozeb in albino mice Bindali,B.B.;Kaliwal,B.B. https://doi.org/10.2486/indhealth.40.191
  12. Ind. Health v.35 no.1 Induction of gonadal toxicity to male rats after chronic exposure to mancozeb Kackar,R.;Srivastava,M.K.;Raizada,R.B. https://doi.org/10.2486/indhealth.35.104
  13. Ann. N Y Acad. Sci. v.982 Results of long-term experimental studies on the carcinogenecity of ethylene-bis-dithiocarbamate (Mancozeb)in rats Belpoggi,F.;Soffritti,M.;Guarino,M.;Lamvertini,L.;Cevolani,D.;Maltoni,C. https://doi.org/10.1111/j.1749-6632.2002.tb04928.x
  14. Carcinogenesis v.14 no.5 Promoting effects of mancozeb on pancreas of nitrosomethylurea-treated rats Monis,B.;Valentich,M.A. https://doi.org/10.1093/carcin/14.5.929
  15. Teratology v.14 Studies of teratogenic effects of the dithiocarbamates Maneb, Mancozeb, and Propineb Larsson,K.S.;Arnander,C.;Cekanova,E.;Kjellberg,M. https://doi.org/10.1002/tera.1420140208
  16. Arch. Environ. Health v.51 no.6 Imunomodulatory effects of occupational exposure to Mancozeb Colosio,C.;Barcellini,W.;Maroni,M.;Alcini,D.;Bersani,M.;Cavallo,D.;Galli,A.;Meroni,P.;Pastorelli,R.;Rozzardi,G.P.;Soleo,L.;Foa,V. https://doi.org/10.1080/00039896.1996.9936044
  17. J. Endodon. v.24 Effects of dentin bonding agents on macrophage mitochondrial activity Rakich,D.R.;Wataha,J.C.;Lefebvre,C.A.;Weller,R.N. https://doi.org/10.1016/S0099-2399(98)80071-X
  18. Cell & Tissue Culture; Laboratory procedures Dolye,A.;Griffiths,J.B.;Newell,D.G.
  19. Immunol. v.14 Further improvements in the plaque technique for detecting single antibody-forming cells Cunninghan,A.;Szenberg,A.
  20. Fundam, Appl. Toxicol. v.14 Immunotoxicity of the pyrrolizidine alkaloid monocrotaline following subcronic administration to C57B1/6 mice Deyo,J.A.;Kerkvliet,N.I. https://doi.org/10.1016/0272-0590(90)90308-7
  21. Kor. J. Toxicol. v.7 Hematological values in normal laboratory mice (ICR and ddY strains) Guest,I.C.;Paik,N.W.;Ryu,J.C.;Park,J.S.;Chang,I.M.