YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Hexane Extract of Acori graminei Rhizoma on Chloramphenicol Acetyltransferase of Staphylococcus aureus SA2

석창포 헥산 추출물이 Staphylococcus aureus SA2의 Chloramphenicol Acetyltransferase 에 미치는 영향

  • Published : 2004.02.01
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Abstract

One subfraction from the hexane fraction of Acri graminei Rhizoma, the E4 fraction which is mainly consisted of acorenone, showed a potential inhibitory activity against chloramphenicol acetyltransferase (CAT) of S. aureus SA2 that is a multidrug-resistant strain to 10 usual antibiotics. The combination therapy of this fraction with chloramphenicol resulted in reduction of the minimal inhibitory concentration from 128 $\mu\textrm{g}$/ml to 8 $\mu\textrm{g}$/ml. The E4 fraction also revealed to prevent the induction of CAT from this strain.

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References

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