Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제30권3호
  • /
  • Pages.181-185
  • /
  • 2004
  • /
  • 2234-7550(pISSN)
  • /
  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

구강편평세포암종 환자에서의 혈액 점도와 혈액 변형성 변화에 대한 연구

CHANGE OF BLOOD VISCOSITY AND DEFORMABILITY IN ORAL SQUAMOUS CELL CARCINOMA PATIENTS

  • 윤필영 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 명훈 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 이종호 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 정필훈 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 김명진 (서울대학교 치과대학 구강악안면외과학교실)
  • Yun, Pil-Young (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Myoung, Hoon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Lee, Jong-Ho (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Choung, Pill-Hoon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Kim, Myung-Jin (Department of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University)
  • 발행 : 2004.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Malignant tumor have hypoxic cell fraction, which makes radio-resistant and hypoxia in tumor is a result from the blood flow decrease caused by increase in blood flow resistance. Blood viscosity increase is major factor of increased blood flow resistance and it could be attributed to the decrease in blood deformability index. For the evaluation of the change of blood viscosity and blood deformability in oral squamous cell carcinoma, we perform the test of the change of those factors between the normal control group and oral squamous cell carcinoma cell patient group. Relative viscosity measured against distilled water was $5.25{\pm}0.14$ for normal control group, and $5.78{\pm}0.26$ for the SCC patient group and there was statistical significance between the groups. However, there was no significant difference between the groups in blood viscosity between the groups by tumor size (T1+T2 vs T3+T4). Also, there was no significant difference between the normal control group and SCC patient group in blood deformability index and between the groups by tumor size (T1+T2 vs T3+T4). Increase in blood viscosity was confirmed with this study and it can be postulated that modification blood viscosity might contribute to decrease of hypoxia fraction in oral squamous cell carcinoma, thus improve the effect of radiotherapy and it can be assumed that the main factor of blood viscosity increase is not decrease of blood deformability in oral squamous cell carcinoma.

키워드

참고문헌

  1. Powers WE, Tolmach LJ : A multicomponent x-ray survival curve for mouse lymphosarcoma cells irradiated in vivo. Nature 1963;16;197:710-711
  2. Denekamp J, Fowler JF, Dische S : The proportion of hypoxic cells in a human tumor. Int J Radiat Oncol Biol Phys 1977;2(11-12):1227-1228 https://doi.org/10.1016/0360-3016(77)90140-7
  3. Moulder JE, Rockwell S : Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 1984;10(5):695-712 https://doi.org/10.1016/0360-3016(84)90301-8
  4. Hall EJ : The oxygen effect an reoxygenation. In Radiology for the radiologist. (4th Ed)J. B. Lippincott, Philadelphia 1994:pp133-152
  5. Falk P : The vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia. Eur J Cancer 1980;16(2):203-217 https://doi.org/10.1016/0014-2964(80)90152-8
  6. Bugajski A, Nowogrodzka-Zagorska M, Lenko J, Miodonski AJ : Angiomorphology of the human renal clear cell carcinoma. A light and scanning electron microscopic study Virchows Arch A Pathol Anat Histopathol 1989;415(2):103-113
  7. Miller B, Heilmann L : During treatment. Cancer. 15;62(2):350-354. Hemorheologic variables in breast cancer patients at the time of diagnosis, 1988
  8. Park SW : Study of blood viscosity and blood deformability in malignant tumor patient. SNUMC 2002
  9. Oh DH : Effect of Ginko biloba extract on the mouse erythrocyte deformability. SNUMC 1996
  10. Reid HL, Barnes AJ, Lock PJ, Dormandy JA, Dormandy TL : A simple method for measuring erythrocyte deformability. J Clin Pathol 1976;29(9):855-858 https://doi.org/10.1136/jcp.29.9.855
  11. Thomlinson RH, Gray LH : The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955;9(4):539-549 https://doi.org/10.1038/bjc.1955.55
  12. Miller B, Heilmann L : Hemorheological parameters in patients with gynecologic malignancies. Gynecol Oncol 1989;33(2):177-181 https://doi.org/10.1016/0090-8258(89)90546-5
  13. Mokken FC, Kedaria M, Henny CP, Hardeman MR, Gelb AW : The clinical importance of erythrocyte deformability, a hemorrheological parameter. Ann Hematol 1992;64(3):113-122 https://doi.org/10.1007/BF01697397
  14. Mohandas N, Chasis JA : Red blood cell deformability, membrane material properties and shape: regulation by transmembrane, skeletal and cytosolic proteins and lipids. Semin Hematol 1993;30(3):171-192
  15. Cohen MH : Impairment of red blood cell deformability by tumor growth. Natl Cancer Inst. 1979;63(2):525-526
  16. Sevick EM, Jain RK : Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia. Cancer Res 1991;15;51(10):2727-2730
  17. Dintenfass L, Fu-lung L : Plasma and blood viscosities, and aggregation of red cells in racehorses. Clin Phys Physiol Meas 1982;3(4):293-301 https://doi.org/10.1088/0143-0815/3/4/005
  18. Horii K, Kubo S, Hirohashi K, Kinoshita H : Changes in erythrocyte deformability after liver resection for hepatocellular carcinoma associated with chronic liver disease. World J Surg 1999;23(1):85-90 https://doi.org/10.1007/s002689900570
  19. Boring CC, Wquires TS, Tong T : Cancer statistics. Cancer J. Clin 1992;42:19-38
  20. Wong DTW, Todd R, Tsuiji T, Donoff RB : Molecular biology of oral cancer. Crit Rev Oral Biol 1996;7:319-328 https://doi.org/10.1177/10454411960070040201