BIOLOGIGIC MEMBRANE FOR GUIDED BONE REGENERATION

골 재생을 위한 생물학적 유도막

  • Hong, Jong-Rak (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Kang, Na-Ra (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University) ;
  • Choung, Pill-Hoon (Department of Oral & Maxillofacial Surgery, College of Dentistry, Seoul National University)
  • 홍종락 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 강나라 (서울대학교 치과대학 구강악안면외과학교실) ;
  • 정필훈 (서울대학교 치과대학 구강악안면외과학교실)
  • Published : 2004.02.28

Abstract

The purpose of this study was to evaluate the stability and efficacy of biologic membrane made of freeze-dried cartilage as a barrier to facilitate guided bone regeneration in experimental non-healing bone defects in the rat mandible. Nine adult Sprague-Dawley rats (400-500g) were used in experiment. 5.0mm in diameter were created on the mandibular angle area by means of slow-speed trephine drill. In microscopic examination, dynamic immature bone forming at 2 weeks and its calcification at 4 weeks were observed. The membrane made of lyophilized cartilage taken from human costal cartilage seems to be very effective for guided bone regeneration as a biologic membrane and the scaffold for attachment of cells or local drug delivery system of growth factor, which may meet the ideal requirement of a barrier membrane and graft materials.

Keywords

References

  1. Campbell JB, Bassett CAL: The surgical application of monomolecular filters(Milipore) to bridge gaps in peripheral nerves and to prevent neuroma formation. Surg Forum 1956;7:570-572
  2. Hurley AL, Stinchfield FE, Bassett CAL, Lyon WH : The role of soft tissues in osteogenesis. J Bone Joint Surg (Am) 1959;41A:1243-1254
  3. Murray G, Holden R, Roachlau W: Experimental and clinical study of new growth of bone in a cavity. Am J Surg 1957;93:385-387 https://doi.org/10.1016/0002-9610(57)90827-9
  4. Boyne PJ: Regeneration of alveolar bone beneath cellulose acetate filter implants. J Dent Res 1964;43:827
  5. Dahlin C: Scientific background of guided bone regeneration. In : Buser D, Dhalin C, Schenk RK, eds. Guided Bone Regeneration in Implant Dentistry. Chicago, Quintessense Publishing Co., pp 31-48, 1994
  6. Scantlebury TV: 1982-1992: A decade of technology development for guided tissue regeneration. J Periodontol 1993;64:1129-1137 https://doi.org/10.1902/jop.1993.64.11s.1129
  7. Choung PH, Lee W, Nam IW: Allogenic lyophilized cartilage grafts for craniomaxillofacial reconstruction. Proceedins of the 4th International Congress of Oral Cancer Vol IV A: 281, 1995
  8. Donath K, Breuner GA: A method for the study of undecalcified bones and teeth with attached soft tissue. J Oral Pathol 1982;11:318-326 https://doi.org/10.1111/j.1600-0714.1982.tb00172.x
  9. Linde A, Thoren C, Dahlin C: Creation of new bone by an osteopromotive membrane technique: An experimental study in rats. J Oral Maxillofac Surg 1993;51:892-897 https://doi.org/10.1016/S0278-2391(10)80111-9
  10. Dahlin C, Lindhe A, Gottlow J, Nyman S: Healing of bone defects by guided tissue regeneration. Plast Reconstr Surg 1988;81:672-676 https://doi.org/10.1097/00006534-198805000-00004
  11. Bluhm AE, Laskin DM: The effect of polytetrafluoroethylene cylinders on osteogenesis in rat fibular defects ; A preliminary study. J Oral Maxillofac Surg 1995;53:163-166 https://doi.org/10.1016/0278-2391(95)90395-X
  12. Dahlin C, Alberius P, Lindhe A: Osteopromotion of cranioplasty; An experimental study in rats using a membrane technique. J Neurosurg 1991;74 :487-491 https://doi.org/10.3171/jns.1991.74.3.0487
  13. Dahlin C, Gotttlow J, Lindhe A, Nyman S: Healing of maxillary and mandibular bone defects using a membrane technique; An experimental study in monkeys. Scan. J Plast Reconstr Hand Surg 1990;24:13-19
  14. Aukhil I, Petterson E, Suggs C: Guided tissue regeneration; An experimental procedure in beagle dogs. J Periodontol 1986;57:727-734 https://doi.org/10.1902/jop.1986.57.12.727
  15. Lekovic V, Kenny EB: Guided tissue regeneration using calcium phosphate implants together with different membranes ; A study on furcations in dogs. J Periodontol 1993;64:1154-1156 https://doi.org/10.1902/jop.1993.64.11s.1154
  16. Barry KB, James AC: Evauation of a high-density polytetrafluorethylene(n-PTFE) membrane as a barrier matrial to facilitate guided bone regeneration in the rat mandible. J Oral Implant 1995;21:88-95
  17. 장도근, 송재철, 이용규, 김진수: 가토하악골 결손부의 골재생에 있어서 n-PTFE의 효과. 대한구강악안면외과학회지 1997;23:487-496
  18. 조세인, 여환호, 김영균, 임석균: An experimental study on GTR technique using lyodura and microfilter in rat’s osseous defects. 대한구강악안면외과학회지 1995;21:535-539
  19. Garrett S, Martin M, Egelberg J: Treatment of periodontal furcation defects; Coronally positioned flaps versus dura mater membranes in class III defects. J Clini Periodontol 1990;17:179-185 https://doi.org/10.1111/j.1600-051X.1990.tb01083.x
  20. Yukna RA: Clinical human comparison of e-PTFE barrier membranes and freeze-dried dura mater allografts for guided tissue regeneration of lost periodontal support. I. mandibular molar class II furcations. J Periodontol 1992;63:431-442 https://doi.org/10.1902/jop.1992.63.5.431
  21. Fontana E, Trisi P, Diatteli A: Freeze-dried dura mater for guided tissue regeneration in post-extraction dental implants: a clinical and histologic study. J Periodontol 1994;65:658-665 https://doi.org/10.1902/jop.1994.65.7.658
  22. Robert PM, Frank RM: Periodontal guided tissue regeneration with a new resorbable polylactic acid membrane. J Periodontol 1994;65:414-422 https://doi.org/10.1902/jop.1994.65.5.414
  23. Lundgren D, Nyman S, Mathisen T, Isaksson S, Klinge B: Guided tissue regeneration of cranial defects using biodegradable barriers: An experimental pilot study in the rabbit. J Craniomaxillofac Surg 1992;20:257-260 https://doi.org/10.1016/S1010-5182(05)80438-X
  24. Galgut P, Pitrola R, Waite I, Doyle C, Smith R: Histological evaluation of biodegradable and non-degradable membranes placed transcutaneously in rats. J Clin Periodontol 1991;18:581-586 https://doi.org/10.1111/j.1600-051X.1991.tb00093.x
  25. Blumenthal NM: A clinical comparison of collagen membranes with e-PTFE membranes in the treatment of human mandibular buccal class II furcation defects. J Periodontol 1993;64: 925-933 https://doi.org/10.1902/jop.1993.64.10.925
  26. Mundell RD, Mooney MP, Siegel MI, Losken A: Osseous guided tissue regeneration using a collagen barrier membrane. J Oral Maxillofac Surg 1993;51:1004-1012 https://doi.org/10.1016/S0278-2391(10)80045-X
  27. Morain WD, Colby ED, Stauffer ME, Russell CL, Astorian DG: Restoration of orbital wall fenetrations with polyglactin 910 film. Plast Reconstr Surg 1987;80:769-774 https://doi.org/10.1097/00006534-198712000-00001
  28. 손재희, 김종렬: 다양한 차단막을 이용한 가토 골결손부의 골조직 유도 재생술에 관한 실험적 연구. 대한구강악안면외과학회지 1997;23:474-486
  29. Caton J, Firanty B, Greenstein G: Synthetic biodegradable barrier for regenertion in human periodontal defects. J Periodont Res 1990;69:275
  30. Hardwick R, Hayes BK, Flynn C: Devices for dentoalveolar regeneration: An up-to-date literature review. J Periodontol 1995;66:495-505 https://doi.org/10.1902/jop.1995.66.6.495
  31. Aukhil I, Simpson DM, Schaberg TV. An experimental study of new attachment procedure in beagle dogs. J Periodontal Res 1983;18:643-654 https://doi.org/10.1111/j.1600-0765.1983.tb00401.x
  32. Grevstad HJ: Effect of subperiosteally implanted polytetrafluoethylene(PTFE) material on alveolar bone in the rat. Scan J Dent Res1993;101:224-228
  33. Tempro PJ, Nalbandian J: Colonization of retrieved polytetrafluoroethylene memebranes: Morphological and microbiological observations. J Periodontol 1993;64:162-1618 https://doi.org/10.1902/jop.1993.64.3.162
  34. Becker W, Becker B, Berg L, Prichard J, Caffesse R, Rosenberg E: New attachment after treatment with root isolation procedures: reports for treated class III and I furcations and vertical osseous defects. Int J Periodont Restorative Dent 1988;3:2-16
  35. 최성호, 김준일, 문익상, 조규성, 채중규, 김종관 : Dura mater가 성견 3급 분지부 병소의 치유에 미치는 영향. 대한치주과학회지 1996;26:591-604
  36. Mannai C: Histologic evaluation of purified bovine tendon collagen sponge in tooth extraction sites in dogs. Oral Surg Oral Med Oral Pathol 1986;61:315-323 https://doi.org/10.1016/0030-4220(86)90408-1
  37. Stein MD, Salkin LM, Freedman AL, Glushko V: Collagen sponge as a topical hemostatic agent in mucogingival surgery. J Periodontol 1985;56:35-38 https://doi.org/10.1902/jop.1985.56.1.35
  38. O'Connor GB, Pierce GW: Refrigerated cartilage isografts. Surg Gynec Obstet 1938;67:796
  39. Straith CL: Grafts of preserved cartilage in restorations of facial contour. J Amer Med Ass 1941;116:2008
  40. Blackstone CH, Parker ML: Rebuilding the resorbed alveolar ridge. J Oral Surg 1956;14:45-57
  41. Boyne PJ, Cooksey DE: Use of cartilage and bone implants in restoration of edentulous ridges. J Am Dent Assoc 1965;71:1426-1435
  42. Rassumowska D: The influence of lyophilized bone in periodentopathy. Acta Med Pol 1970;11:303-307
  43. Sailer HF: Experiences with the use of lyophilized bank cartilage for facial contour correction. J Oral Surg 1976;4:149-157 https://doi.org/10.1016/0030-4220(51)90429-X
  44. Sailer HF: Transplantation of lyophilized cartilage in maxillofacial surgery. Basel, NY : Krager. 1983
  45. Davis WM: Replacement of freeze-dried allogenic cartilage chin graft with host bone. Oral Surg Oral Med Oral Pathol 1992;73:541-542 https://doi.org/10.1016/0030-4220(92)90092-5
  46. 정필훈: 냉동건조 은행골의 개발 및 이의 실험적 연구. 대한악안면성형재건외과학회지 1996;18: 164-174
  47. 정필훈: 유리골 이식을 통한 하악골 결손부의 기능적 재건술. 대한악안면성형재건외과학회지 1993;15:338-343
  48. 이기웅, 남일우: 골 결손부 처치에 있어 생체 흡수성 차폐막에 의한 유도 골 재생에 대한 실험적 연구. 서울치대논문집 1996;20:154-184